CD4+ T cellsToleranceIt has long been known that the B cell repertoire includes cells that are capable of producing autoantibodies and that these cells can be found in humans and also in wild type strains of la
Follicular helper CD4 T cells (T FH ). Annu. Rev. Immunol. 29, 621–663 (2011). 27. Schmitt, N. & Ueno, H. Regulation of human helper T cell subset differentiation by cytokines. Curr. Opin. Immunol. 34, 130–136 (2015). 28. Becattini, S. et al. Pathogens or Vaccines. Science...
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708–712 (1999). Article CAS PubMed Google Scholar Crotty, S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29, 621–663 (2011). Article CAS PubMed Google Scholar Derh...
Clusters A1, B1, and E1 included cells expressing Tbx21 (encoding T-bet, characteristic of Th1 cells), Bcl6 (T follicular helper [Tfh] cells), and Foxp3 (regulatory T [Treg] cells) (Figure 1C). Cluster D1 cells expressed genes, including Il7r, Bcl2, and Ccr7, that are typical of...
4a), we reasoned that CLTCH129>Q-specific CD4+ T cell-mediated protection may be dependent on their role as helper cells for CD8+ T cells19. Consistent with this, depletion of CD8+ T cells before the transfer of CD4+ T cells and tumor inoculation prevented tumor rejection (Fig. 4f). ...
In the case of viral infections, these usually include “follicular helper” CD4+ T (Tfh) cells that induce B cells to produce high-affinity antibodies capable of neutralizing the pathogen and cytolytic CD8+ T cells that kill pathogen-infected cells. Clonal diversity in the pre-immune “naive...
Despite the effective antiretroviral treatment (ART) of HIV-infected individuals, HIV persists in a small pool. Central memory CD4+ T cells (Tcm) make a major contribution to HIV persistence. We found that unlike HLA-DR, CD38 is highly expressed on the T
STAT6 Activation Confers Upon T Helper Cells Resistance To Suppression By Regulatory T Cells 热度: tcr itam multiplicity is required for the generation of follicular helper t-cells:tcr itam的多样性是滤泡辅助性t细胞的生成所需的 热度: IL2和IL7在调控调节性T细胞和记忆性T细胞的产生和功能中的新作用机...
T follic- ular helper (Tfh) cells are located in germinal centers and are characterized by an increased expression of CXCR5, PD-1, ICOS, CD40L, interleukin (IL)-21, and the transcription factor Bcl-6. Furthermore, activated Tfh cells can be defined as ICOS + CD4 + CXCR5 + [11]. Tfh...
Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–peptide complexes to control phagosomal infections, help B cells, regulate tissue homeostasis and repair or perform immune regulation. Memory CD4+ T cells are po