Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood. 2008; 112 :2539–45.Folgueras AR, de Lara FM, Pendas AM, et al. Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood. 2008;112(...
Seprase could be affinity-labeled by [3H]diisopropyl fluorophosphate, but the proteolytically inactive 97-kDa subunit could not, confirming the existence of a serine protease active site on the dimeric form. Proteolytic activity is lost upon dissociation into its 97-kDa subunit following treatment ...
Studies suggest that the actions of insulin on glucose metabolism may be mediated through activation of a membrane-bound serine protease with properties similar to a kallikrein-like enzyme. Also, bradykinin, a vasoactive product of kalli... N Shimojo,TG Pickens,HS Margolius,... - Biological Chem...
The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. TMPRSS2 protein is abundantly expressed in the prostate, with low levels in the epithelia of the colon, stomach, epididymis and breast. Pancreatic acini,... JM Lucas,L ...
Factor VIII, a cofactor of the intrinsic clotting pathway, is proteolytically inactivated by the vitamin K-dependent serine protease, activated protein C i... PJ Fay,JV Coumans,FJ Walker - 《Journal of Biological Chemistry》 被引量: 496发表: 1991年 SopA, the outer membrane protease responsible...
Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes. Induction of cleavage of L-selectin via CD16. J Immunol. 1994;152(3):1314–22. CAS PubMed Google Scholar Bazil V, Strominger JL. CD43, the major sialoglycoprotein of ...
CDKs are a family of serine/threonine protein kinases that are activated at specific points of the cell cycle and are regulated by several different mechanisms.3 CDK inhibitors function through inhibition of the G1 CDK cyclin complexes.4 Furthermore, the CDK inhibitor p21 has the ability to ...
Yano A, Suzuki K, Shinshi H: A signaling pathway, independent of the oxidative burst, that leads to hypersensitive cell death in cultured tobacco cells includes a serine protease. Plant J. 1999, 18 (1): 105-109. Article CAS Google Scholar Marchenko ND, Marchenko GN, Strongin AY: Unconv...
L., and Fraser, C., 1977, Thrombin, collagen and A23187 stimulated endogenous platelet arachidonate metabolism: differential inhibition by PGE, local anesthetics and a serine-protease inhibitor, Prostaglandins 14: 1075. Ferber, E., Munder, P. G., Fischer, H., and Gerisch, G., 1970, High...
In addition, PKCδ inhibitor treatment induced a decrease in tyrosine phosphorylation as well as decreased activation of MAPKs and Akt, other serine/threonine-specific protein kinase (Fig. 4c,d; Supplementary Fig. S2d). These findings indicated that M-CSF signalling controls various kinases, ...