pH maintenance is a result of the combinational function of multiple ion transport proteins. Thus, ion homeostasis in melanosomes is crucial for melanin synthesis. Defect of the ion transport system causes various pigmentation phenotypes, from mild effect to severe disorders such as albinism. In ...
The mechanism of transport for all such transport proteins has been conceived as a ‘rocker switch’ or ‘gated pore’ model. “The former focused on the rocking movements of protein domains pivoting at the substrate binding site; the latter emphasized local motions of outside and inside gates,...
Four transport proteins have been recently identified and functionally characterized inArabidopsisso far: one transporter for the import of fatty acids and three carrier proteins for the uptake of the cofactors ATP and NAD into plant peroxisomes. The transport of the three substrates across the ...
Transport proteins of the plant plasma membrane 来自 Semantic Scholar 喜欢 0 阅读量: 29 作者:SM Assmann,LL Haubrick 摘要: Recently developed molecular and genetic approaches have enabled the identification and functional characterization of novel genes encoding ion channels, ion carriers, and water ...
Membrane-associated proteins that govern the transport of solutes (for example, drugs and other xenobiotics) into and out of cells. Transporters can play a vital role in determining drug concentrations in the systemic circulation and in cells. The two major superfamilies of membrane transporters are...
Membrane proteins are proteins found in cell membranes, either at the surface or on intracellular organelles. Integral membrane proteins such as receptors and ion channels span the membrane. Peripheral membrane proteins, for example some signalling proteins, are tethered by an anchor, via a fatty aci...
there has been accelerating progress in defining these mechanisms in terms of the epithelial transport processes occurring in defined regions of the nephron. This review focuses on recent evidence that has accumulated concerning the effect of aldosterone on membrane transport processes. In developing this...
1. Gap junctions. These connect two adjacent cell membranes by proteins that form pores or channels between the cells so that materials can diffuse more quickly from cell to cell. 2. Tight junctions. Protein molecules on the surface of adjacent cells form tight junctions that are ...
Cancer cells overexpress growth factor receptors (e.g., EGFR and IGF-1) and adherent proteins (e.g., integrins, CD44, and CD24) involved in tumor progression and invasion on their cell membranes. This contributes to cancer cells membrane-specific characteristics such as homotypic targeting, ...
The endosomal sorting complexes required for transport (ESCRT) machinery consisting of cytosolic protein complexes, known as ESCRT-0, ESCRT-I, ESCRT-II and ESCRT-III. Together with a number of accessory proteins, these ESCRT complexes enable membrane remodelling that results in membranes bending/buddi...