Thousands of transport processes, each catalyzed by its own protein, have been identified; however, there are relatively few strategies found in coupling metabolic energy to the translocation process. The chapter describes these strategies to provide a formal basis for a preliminary classification of ...
1.4.A1 Structure and function of the sodium-potassium pumps for active transport and potassium channels for facilitated diffusion in axons. 钠钾泵(sodium-potassium pump)是一个必须掌握的主动运输知识点,很多类型细胞里面都有钠钾泵(泵其实是globular protein),比如第六章里面的神经细胞会具体讲到,这一节要...
It is very important that, for a symporter or antiporter, an ion never moves through the transport protein on its own, as then the energization of transport of substrate would be wasted as heat and other transmembrane processes requiring a transmembrane electrochemical gradient of ions (e.g., ...
Structure of an ABC transporter in complex with its binding protein . Nature 446 , 213–216 10.1016/j.sbi.2007.07.003 [ Cross Ref ]... K Hollenstein,RJ Dawson,KP Locher - 《Current Opinion in Structural Biology》 被引量: 809发表: 2007年 The major intrinsic protein (MIP) of the bovine...
The first structures, determined 20 years ago, were those of naturally abundant proteins with limited conformational variability, and each membrane protein structure determined was a major landmark. With the advent of complete genome sequences and efficient expression systems, there has been an ...
During active transport, ATP is required to move a substance across a membrane, often with the help of protein carriers, and usuallyagainstits concentration gradient. One of the most common types of active transport involves proteins that serve as pumps. The word “pump” probably conjures up ...
OAT1 has a fundamental role in the kidney by facilitating the urinary excretion of various drugs and endogenous metabolites. Two studies now present high-resolution structures of OAT1 using cryo-EM, elucidating its intricate polyspecific transport capabilities and paving the way for structure-based dr...
The X-ray structure of the drug/metabolite transporter (DMT) protein YddG fromStarkeya novellareveals a new membrane transport topology, with ten transmembrane segments in an outward-facing state and two pseudo-symmetric inverted structural repeats. ...
摘要: Compared to the extremely large volume of work that has been done on the structure of the nuclear pore complex and transport through its central channel, the question of how integral membrane proteins get to the inner nuclear membrane has been largely...
Integral protein:部分或全部包埋在磷脂双分子层中,这类型蛋白质是amphipathic分子 Peripheral protein:连在磷脂双分子层的任意一边,这类型蛋白质是不含疏水区域,因为不贯穿膜 不同类型细胞的细胞膜因为有不同蛋白质分子的附着,表现出不一样的功能。在下一节讲到细胞膜的选择透过性时,蛋白质对这个功能起着重要作用。