Membrane proteins (MPs) play a key role in mediating intercellular communication and transducing signals in cells through interacting proteins and downstream cellular processes1. Alterations in MPs and their regulated pathways, involved in the formation and progression of human cancers1,2, have been use...
3.(Biology)biologya double layer of lipid, containing some proteins, that surrounds biological cells and some of their internal structures 4.(Atomic Physics)physicsa two-dimensional entity postulated as a fundamental constituent of matter in superstring theories of particle physics ...
In addition, we confirm that T cell membrane proteins present in SMALPs can be readily immunoisolated. Our results support the use of SMA as a potentially better (less artifact prone) alternative to detergents for studies on membrane proteins and their complexes, including membrane rafts. ...
The interactions between membrane proteins and their lipid bilayer environment play important roles in the stability and function of such proteins. Extended (15–20 ns) molecular dynamics simulations have been used to explore the interactions of two membrane proteins with phosphatidylcholine bilayers. One...
Membrane adhesion and other functions for the myelin basic proteins (p 13-18)The myelin basic proteins are a set of peripheral membrane polypeptides which play an essential role in myelination. Their most well-documented property is the unique ability to seal the cytoplasmic aspects of the myelin...
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of small conserved eukaryotic proteins that mediate membrane fusion between organelles and with the plasma membrane. SNAREs are directly or indirectly anchored to membranes. Prior to fusion, complementary SNAREs ass...
Membrane protein research has flourished in the past 20 years. Exciting technological innovations in structural biology, including cryoEM single-particle analysis and AI-based protein structure prediction, such as AlphaFold 2, have largely revolutio
Membrane proteins are critical to diverse physiological functions and are directly implicated in many diseases. They represent one-third of the genome and 60% of the known drug targets [1]. Thus, it is important to be able to examine the cellular context in which membrane proteins interact with...
The cell membrane is primarily composed of a mix ofproteinsandlipids. Depending on the membrane’s location and role in the body, lipids can make up anywhere from 20 to 80 percent of the membrane, with the remainder being proteins. While lipids help to give membranes their flexibility, protei...
Membrane proteins are critical to diverse physiological functions and are directly implicated in many diseases. They represent one-third of the genome and 60% of the known drug targets [1]. Thus, it is important to be able to examine the cellular context in which membrane proteins interact with...