Previous studies have established that the folding, structure and function of membrane proteins are influenced by their lipid environments1,2,3,4,5,6,7 and that lipids can bind to specific sites, for example, in potassium channels8. Fundamental questions remain however regarding the extent of mem...
a wide range of protein functions, but their design has been neglected owing to a lack of accurate computational tools. Now it is shown that allosteric signalling membrane proteins can be engineered through such networks, revealing a broader space of designable protein interactions and functions. ...
Membrane adhesion and other functions for the myelin basic proteins (p 13-18)The myelin basic proteins are a set of peripheral membrane polypeptides which play an essential role in myelination. Their most well-documented property is the unique ability to seal the cytoplasmic aspects of the myelin...
Many of these substrates were identified by incubating recombinant soluble MT-MMP proteins with potential substrate in a test tube, whereas others were identified in cell culture systems and by proteomics approaches. While some of the substrates were confirmed to be physiological substrates, some of ...
2. Chaperones and their regulation 2.1. Classification and basic functions of stress protein chaperones There are many different families of HSP chaperones, each family acting to aid protein folding in a different way. Below, we give a brief survey of the major classes of these proteins. Table ...
3.(Biology)biologya double layer of lipid, containing some proteins, that surrounds biological cells and some of their internal structures 4.(Atomic Physics)physicsa two-dimensional entity postulated as a fundamental constituent of matter in superstring theories of particle physics ...
The plasma membrane is made primarily of lipids and proteins. The lipid bilayer is made up of phospholipids, glycolipids, and cholesterol. About half the mass of the plasma membrane is made up of proteins that have specialized membrane functions. These proteins consist of integral and peripher...
* Membrane proteins that take on a more globular shape, instead of the rodlike structure previously described, are often involved with transport activities and other functions requiring a substantial portion of the peptide to be embedded in the membrane. These proteins may consist of numerous ...
and expression of G-protein-coupled receptors (GPCRs) that comprise the largest family of membrane proteins. Data are presented on hereditary diseases caused by genetic deficiencies of receptors, and on oncological diseases caused by somatic mutations of GPCR(s) and G-protein(s) genes. The ...
The plasma membrane (PM) constitutes the outer boundary of the plant cell. As such, it functions in communication with the neighboring cells and with the environment. Moreover, the PM serves as the principal barrier for the small molecules that enter or