These protein complexes are critical to the development and physiology of growing fungal cells and have attracted attention as promising therapeutic candidates against invasive mycoses. 2. At the end of the third paragraph, we replaced discussion of GS with elaboration of Pma1 and ot...
Selective cargo recycling depends on coat protein complexes that guide the incorporation of specific cargo into vesicles and membrane tubules. Generally, short peptide motifs present in the cytoplasmic tail of transmembrane proteins interact with components of coat complexes, leading to cargo clustering and...
Atomic coordinates and structure factors of the crystallographic complexes are available in the Protein Data Bank (PDB) under accession codes 8A1G and 8ABQ (Table 1). Cryo-ET structures and representative tomograms have been deposited in the Electron Microscopy Data Bank (EMDB) under accession code...
Recent studies suggest that all postsynaptic receptors might be multi-protein complexes that not only scaffold and target the protein to the PSD, but may also attract downstream effectors to the vicinity of the receptor. In addition, excitability of a neuron can be controlled by rapid insertion ...
Several recombinants of human 4.1R80–containing alpaca sequences were used to study their ability to form spectrin–actin–4.1R ternary complex (13) by measuring the viscosity of the complexes and also to examine the ability to interact with β-spectrin (33). The results showed that the exon...
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear.
The biogenesis of PG and LPS relies on specialized macromolecular complexes that span the entire envelope. In this work, we show that Escherichia coli cells are capable of avoiding lysis when the transport of LPS to the OM is compromised, by utilizing LD-transpeptidases (LDTs) to generate 3-...
It is known that polycations bind to and neutralize glomerular polyanions. Here we examine the effect of the polycation polyethyleneimine (PEI) on glomerular deposition of preformed immune complexes. Bovine serum albumin (BSA)-anti-BSA i... Barnes,J. L. - 《Journal of Experimental Medicine》 被...
Finally, there is a need to incorporate more hydrophilic nano-supplement such as MgO, Fe3O4, ZnO, SiO2, Zeolites, Ag, carbon nanotubes (CNTs), etc., in the membrane matrix to strengthen further the membrane properties and selectivity in tackling fouling. Although a growing number of studies...
Despite the finding that phospholipids move rapidly in the plane of the bilayer, this is not a random process. Both lipid and protein organization will lead to domains in the membrane where certain lipids and proteins are enriched. As an example, these microdomains, or “rafts,” are involved...