CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement proteins C8 and C9 at the membrane to prevent insertion and polymerization of membrane attac
【答案】：即膜攻击复合物，由补体系统的C5b～C9组成。该复合物牢固附着于靶细胞表面，最终造成细胞溶解死亡。
【名词解释】膜攻击复合物(membrane attack complex,MAC) 相关知识点: 试题来源: 解析 膜攻击复合物:是三条激活途径的共同末端通路.由附着于细胞膜表面的C5b6~9复合物组成。可在胞膜上形成小孔,使得小的可溶性分子、离子以及水分子自由透过胞膜,最终导致胞内渗透压降低,细胞溶解。反馈 收藏 ...
An important effector function of the human complement system is to directly kill Gram-negative bacteria via Membrane Attack Complex (MAC) pores. MAC pores are assembled when surface-bound convertase enzymes convert C5 into C5b, which together with C6, C7, C8 and multiple copies of C9 forms a...
Define Membrane attack complex. Membrane attack complex synonyms, Membrane attack complex pronunciation, Membrane attack complex translation, English dictionary definition of Membrane attack complex. n. Slang Used as a form of address for a man whose nam
百度试题 结果1 题目膜攻击复合物(membrane attack complex,MAC) 相关知识点: 试题来源: 解析 56℃ 30min 反馈 收藏
The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. The MAC is formed by sequential assembly of soluble complement proteins C5b, C6, C7, C8 and C9, but little is known about the rate-limiting steps in this process...
The "killer molecule" of complement is the membrane attack complex (MAC). It constitutes a supramolecular organization that is composed of approximately 20 protein molecules and has a molecular weight of about 1.7 million. The complex has five precursors, C5, C6, C7, C8, and C9, which are ...
This chapter discusses the membrane attack complex proteins, C5b-6, C7, C8, and C9, of human complements. The cytolytic activity of complement was the first recognized function of the complement system. The five plasma proteins participating in this reaction are C5, C6, C7, C8, and C9 that...
The membrane attack complex (MAC)/perforin-like protein complement component 9 (C9) is the major component of the MAC, a multi-protein complex that forms pores in the membrane of target pathogens. In contrast to homologous proteins such as perforin and the cholesterol-dependent cytolysins (CDCs...