Here we show how the receptor binds complement proteins C8 and C9 at the membrane to prevent insertion and polymerization of membrane attack complex (MAC) pores. We present cryo-electron microscopy structures of two inhibited MAC precursors known as C5b8 and C5b9. We discover that in both ...
CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement proteins C8 and C9 at the membrane to prevent insertion and polymerization of membrane attac
【答案】：即膜攻击复合物，由补体系统的C5b～C9组成。该复合物牢固附着于靶细胞表面，最终造成细胞溶解死亡。
The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. The MAC is formed by sequential assembly of soluble complement proteins C5b, C6, C7, C8 and C9, but little is known about the rate-limiting steps in this process...
【名词解释】膜攻击复合物(membrane attack complex,MAC) 相关知识点: 试题来源: 解析 膜攻击复合物:是三条激活途径的共同末端通路.由附着于细胞膜表面的C5b6~9复合物组成。可在胞膜上形成小孔,使得小的可溶性分子、离子以及水分子自由透过胞膜,最终导致胞内渗透压降低,细胞溶解。反馈 收藏 ...
membrane attack complex, MAC 相关知识点: 试题来源: 解析 C5b-C6-C7-C8-C9复合体 膜攻击复合物(MAC)由补体系统终末途径生成,步骤为C5被裂解为C5a和C5b;C5b与C6、C7结合形成复合体,嵌入细胞膜;随后结合C8,促使多个C9聚合形成跨膜孔道。各成分通过顺序结合形成MAC,导致靶细胞裂解。若原题不完整或描述错误...
A recent burst of new information on MAC structure provides context and opportunity to re-assess the ways in which MAC kills bacteria and modulates cell functions. In this brief review we will describe key aspects of MAC evolution, function and structure and seek to use the new struct...
A recent burst of new information on MAC structure provides context and opportunity to re-assess the ways in which MAC kills bacteria and modulates cell functions. In this brief review we will describe key aspects of MAC evolution, function and structure and seek to use the new structural ...
Define Membrane attack complex. Membrane attack complex synonyms, Membrane attack complex pronunciation, Membrane attack complex translation, English dictionary definition of Membrane attack complex. n. Slang Used as a form of address for a man whose nam
百度试题 结果1 题目膜攻击复合物(membrane attack complex,MAC) 相关知识点: 试题来源: 解析 56℃ 30min 反馈 收藏