Ten mouflon rams were kept with their mothers in a captive regimen under natural photoperiod. Seven of the mouflon lambs received a series of subcutaneous implants containing 18 mg of melatonin (Melovine ). The first implant was inserted at the time of birth and it was followed by implant ...
The animals were randomized into 5 groups: normal group, model group and three melatonin groups (2.5, 5.0, and 10.0 mg/kg), in- trarectally treated with saline, TNBS, and TNBS plus melatonin, respectively. At the end of the 4th wk, macroscopic and histological changes of the colon were ...
Adults (N = 53; 21 men and 32 women) between the ages of 26 and 71 years were administered either 6 mg of melatonin or a placebo for 8 nights. An instructional manipulation directed participants' expectations. Participants rated their nightly sleep experiences. Results revealed that feelings ...
Semin Clin Neuropsychiatry 2000; 5(1):44–55. Nagtegaal JE, Kerkhof GA, Smits MG et al. Delayed Sleep Phase Syndrome: A placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. J Sleep Res 1998; 7:135–143. ...
SUMMARYIn order to investigate the role of melatonin on the neuroregulation of GH secretion, eight healthy male volunteers each underwent four separate tests in random order separated by at least 1 week. Following oral administration of melatonin (500 mg at – 60 min and at – 30 min) plasma...
Normally, 0.5 mg–5 mg of melatonin taken daily before bedtime for up to 6 years has been used for sleep disorders in blind people. Lee et al. showed that co-treatment of colon cancer stem cells with 5-FU (1 μM) and Mel (500 μM) resulted in significant increases of the expression...
Melatonin capsules were implanted in the subcutaneous tissue behind the ears of goats at a dose of 2 mg/kg at 1-month intervals beginning in February [49]. During the anagen phase in May, 1 × 1 cm skin samples were collected from the side of the scapulae. Skin samples were immediately...
The scraped tissue was collected and digested in 3 mg/mL type I collagenase (Sigma-Aldrich, St. Louis, USA) at 37 °C for 1 h. After digestion, tissues were seeded in 6-well plates (Thermo Scientific, Carlsbad, USA) with complete culture medium. The medium was changed every 2...
31.(8分)褪黑素(melatonin)主要是由哺乳动物的松果体产生的一种胺类激素,该激素能改善睡眠质量、调节动物昼夜节律。光暗信号刺激动物的视网膜产生兴奋,经过神经细胞的传递,作用于松果体细胞,松果体细胞释放褪黑素。请回答下列相关问题(1)在光暗信号的刺激下,松果体分泌褪黑素的调节方式为松果体在该调节过程中属于...
MLT was given orally at 20 mg day-1 in the evening, every day starting 7 days before TMX, which was given orally at 20 mg day-1 at noon. A partial response was achieved in 4/14 (28.5%) patients (median duration 8 months). The treatment was well tolerated in all cases, and no ...