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随着年龄的增长,特别是35岁以后,体内自身分泌的褪黑素明显下降,导致睡眠紊乱以及一系列功能失调。体外补充褪黑素,可使体内的褪黑素水平维持在年轻状态,调整和恢复昼夜节律,不仅能加深睡眠,提高睡眠质量,更重要的是改善整个身体的机能状态,提高生活质量等。小剂量(1～3mg)就有较为理想的催眠效果。
测定新型睡眠促进剂 Melatonin的药代动力学参数的方法是以咖啡因为内标,以 GC/ MS的SIM(选择性离子监测 )为检测手段 ,定量测定家兔体内 Melatonin的含量及药代动力学参数.其结果为家兔灌胃给予 Melatonin3 0 mg· kg- 1后 ,Melatonin在家兔体内呈二室分布 ,药代动力学参数为t1/ 2α=0 .3 1 h,t1/ 2β=...
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2 mg controlled-release PO qHS for up to 6 months; taper dose over 6 weeks Cancer, Adjunctive Therapy 10-50 mg PO daily Cluster Headache, Prevention 10 mg PO qHS Migraine Headache 3 mg PO HS Insomnia 3-5 mg PO qHS Difficulty falling asleep 5 mg PO 3-4 hour before sleep period x...
Unlabelled: We aimed to determine the efficacy of melatonin 3 mg/day in prevention of olanzapine-induced metabolic side-effects. In a randomized double-blind placebo-controlled study, 48 patients with first-episode schizophrenia who were eligible for olanzapine treatment, were randomly assigned to ...
Nagtegaal JE, Kerkhof GA, Smits MG et al. Delayed Sleep Phase Syndrome: A placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. J Sleep Res 1998; 7:135–143. CrossRef Kayumov L, Buttoo K, Shapiro CM. De...
Sleep disruption in tetraplegia: a randomised, double-blind, placebo-controlled crossover trial of 3 mg melatonin. Spinal Cord. 2014;52(8):629-34.Sleep disruption in tetraplegia:a randomised,double-blind,placebo-controlled crossover trial of 3mg melatonin. Spong J,Kennedy G A,Tseng J,et al...
评价(0) 货号: ajci15478 CAS: 73-31-4 别名: 褪黑素; N-Acetyl-5-methoxytryptamine 分子式: C13H16N2O2 分子量: 232.28 纯度: >98% 溶解度: ≥ 23.2mg/mL in DMSO 储存: Store at -20°C 库存: 现货 Background Melatonin is a hormone made by the pineal gland that can act...