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[5] Stalnecker CA, Der CJ. RAS, wanted dead or alive: advances in targeting RAS mutant cancers. Sci Signal. 2020;13:eaay6013. [6] Caunt C J, Sale M J, Smith P D, et al. MEK1 and MEK2 inhibitors and cancer ...
MEK1 and MEK2 inhibitors and cancer therapy: The long and winding road. Nat. Rev. Cancer 2015, 15, 577-592. [CrossRef] [PubMed]Caunt CJ, Sale MJ, Smith PD, et al. MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road. Nat Rev Cancer 2015;15: 577-92....
The Ras/Raf/MAPK Pathway, J Thorac Oncol. 2006 Targeting the Mitogen-Activated Protein Kinase RAS-RAF Signaling Pathway in Cancer Therapy, Expert Opin Ther Targets . 2012 Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy, Cells, 2020 Advances in Targeting the Ras/Raf/MEK/Erk Mito...
Targeting the RAF-MEK-ERK pathway in cancer therapy. The clinical success of selective kinase inhibitors, such as imatinib and erlotinib, as therapeutic agents for several human cancers has prompted substanti... C Montagut,J Settleman - 《Cancer Letters》 被引量: 0发表: 2009年 Roles of the ...
2022年9月12日,四川大学华西医院石虎兵和敬静团队合作在Cell Reports Medicine杂志在线发表题为“PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer”的研究论文。该研究通过全基因组 CRISPR-Cas9 文库筛选,发现抑制PSMG2可使TNBC细胞对MEK抑...
(androgen receptor,AR)信号通路在前列腺癌发生及进展的各个阶段均起着关键作用,配体(双氢睾酮)与AR结合诱导其激活后入核,在细胞核中,AR结合雄激素反应元件ARE(androgen response element),进而发挥转录激活因子的作用,促进肿瘤细胞增殖及侵袭等生物学功能,而针对AR的雄激素剥夺治疗(androgen deprivation therapy, ADT)...
Ovarian Cancer - Angiogenesis and Targeted Therapy Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancies in developed countries. Despite advances in chemotherapy leadin... K Rittiluechai,N Prasongsuk,V Vinh-Hung,... - 《Current Angiogenesis》 被引量: 2发表...
in cancer targeted therapy,”Bioorganic Chemistry 2020,99:103811中所述的那些,所述文献的内容以引用的方式整体并入本文中。在一些实 施方案中,EGFR抑制剂是选自西妥昔单抗、耐昔妥珠单抗、帕尼单抗、扎芦木单抗、尼妥珠单 抗和马妥珠单抗。在一些实施方案中,EGFR抑制剂为西妥昔单抗。在一些实施方案中,EGFR ...
最后,报道指出,TSCM具有显著的召回效应(recall response),而这一效应在抗肿瘤治疗中起到至关重要的作用。作者采用过继性免疫疗法(adoptive cell therapy,简称ACT)肿瘤模型,发现MEKi作用下的CD8+T细胞,起召回效应水平是正常细胞的5倍之多,...