In this review, we comprehensively examine the role of the MEK pathway in carcinogenesis and its therapeutic potential in cancer patients, with a focus on MEKi. We describe the clinical perspectives of MEKi in the two main models of Ras–ERK driven tumors, BRAF-mutant (“addicted” to the ...
Tumours manage to survive the ablation of mutant KRAS, despite the development of KRAS-targeted drugs. Here we describe that inhibition of mutant KRAS promotes MEK nuclear localization as an alternative mechanism of KRAS-targeted drugs resistance. Tissue
Full Name mitogen-activated protein kinase kinase 1 Calculated Molecular Weight 43 kDa GenBank Accession Number BC139729 Gene Symbol MEK1 Gene ID (NCBI) 5604 ENSEMBL Gene ID ENSG00000169032 RRID AB_2881242 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification UNIPROT ID ...
Distant metastasis is the leading cause of cancer-related mortality, and achieving survival benefits through advancements in systemic therapy remains challenging. Mast cells play a dual role in shaping the tumor microenvironment (TME) and influencing dis
Molecular Cancer 2014, 13:45 http://www.molecular-cancer.com/content/13/1/45 RESEARCH Open Access MEK targeting in N-RAS mutated metastatic melanoma Jaykumar Thumar†, David Shahbazian†, Saadia A Aziz, Lucia B Jilaveanu and Harriet M Kluger* Abstract Background: Gain of function ...
The co-administration of MPT0E028 and MEK inhibitor yielded synergistic effects on cell viability suppression both in K-Ras mutated and wild-type pancreatic cancer cells and also markedly triggered cell apoptosis. Surprisingly, ERK and epidermal growth factor receptor (EGFR) were activated by the ...
miR-34a-5p functions as a tumor suppressor in head and neck squamous cell cancer progression by targeting Flotillin-2. Authors - Xiang Li View Article mouse,human WB World J Gastroenterol TATA-box-binding protein-associated factor 15 is a novel biomarker that promotes cell proliferation and migrat...
Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040strongly reduces growth and improves lung structure. BMC Cancer. 2004 Jun 1;4:24. Citations 1.Wu R, Pang S, Lv W, et al.Injectable pH‐Responsive CI1040 Delayed‐Release Hydrogel for the ...
and MAPK). These signaling cascades are often dysregulated in human cancer cells. Many small molecule inhibitors targeting various component of these cascades are moving quickly from bench to bedside [2–4]. For instance, vemurafenib is the first B-RAF inhibitor that received FDA approval in 2011...
Eukaryotic initiation translation factor 3 subunit h (EIF3H) plays critical roles in regulating translational initiation and predicts poor cancer prognosis, but the mechanism underlying EIF3H tumorigenesis remains to be further elucidated. Here, we repor