Park JI. Growth arrest signaling of the Raf/MEK/ERK pathway in cancer. Front Biol (Beijing). 2014; 9: 95-103.Jong-In, Park. (2014) Growth arrest signaling of the Raf/MEK/ERK pathway in cancer. Frontiers in Biology 9 , 95-103 /...
Hedgehog (Hh) signaling is highly conserved fromDrosophilato mammals and plays a crucial role in many aspects of embryonic development, such as neural tube and limb patterning in vertebrates [1,2,3]. In postnatal physiology, Hh pathway has key roles in tissue homeostasis and regeneration in the...
Full size image Trametinib recovers synaptic and network dysfunction in the 5XFAD mouse brain The EPSCs were recorded at the hippocampal CA1 region to compare the LTP between wild-type and 5XFAD mice at the age of 8 months. As reported previously [34], LTP in the 5XFAD-vehicle group was...
浓度:1000 ug/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 humanWB mouseWB Nat Commun ZFP281-BRCA2 prevents R-loop accumulation during DNA replication. mouseWB ACS Appl Mater Interfaces Near-Infrared Light-Responsive Nanoinhibitors for Tumor Suppression through Targeting and Regulating Anion Channels...
Eukaryotic initiation translation factor 3 subunit h (EIF3H) plays critical roles in regulating translational initiation and predicts poor cancer prognosis, but the mechanism underlying EIF3H tumorigenesis remains to be further elucidated. Here, we repor
As known from cancer therapy, deregulated cells might also develop resistance to certain Raf/MEK inhibitors, indicating a reduced susceptibility due to reprogramming of this signaling cascade [18,19]. Furthermore, modulation of activation or inhibition sites in the master gatekeepers MEK1/2 might ...
and MAPK). These signaling cascades are often dysregulated in human cancer cells. Many small molecule inhibitors targeting various component of these cascades are moving quickly from bench to bedside [2–4]. For instance, vemurafenib is the first B-RAF inhibitor that received FDA approval in 2011...
1D). Furthermore, from 59 paired CRC and normal tissues, IMP3 mRNA levels were at least twofold higher in cancerous tissue than in normal tissue in nearly 70% of pairs (41/59, Fig. 1E). IHC and western blot analysis found that IMP3 protein levels were higher in CRC tissues compared...
Positive WB detected in HeLa cells, K-562 cells, MCF-7 cells Positive IHC detected in human breast cancer tissueNote: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 推荐稀释比 ApplicationDilution Western Blot (...
RAF family kinases have prominent roles in cancer1. Their activation is dependent on dimerization of their kinase domains, which has emerged as a hindrance for drug development2,3. In mammals, RAF family kinases include three catalytically competent enzymes (ARAF, BRAF and CRAF) and two pseudokina...