Within the traditional batik workplaces of five districts in Yogyakarta province, an inventory of chemical exposures was undertaken alongside a cross-sectional study. Interviews and examinations of the workers, using the Nordic Occupational Skin Questionnaire-2002/LONG, were carried out due to the ...
aThe mechanism of sustainable release of MCL by ACT001 under neutral conditions. The chemical structure of ACT001 and MCL were shown as indicated.b,cThe suppressive effect of ACT001 on proliferation was determined by CCK-8 assay. As ACT001 concentration increased, the viability of GH3 cells (b, ...
Full size image Western blotting was then performed to validate the proteomic data (Fig.6H). The results revealed that LNT-UsSeNPs increased the expression of proteins within the PI3K-AKT-mTOR signaling pathway and simultaneously suppressed the expression of the translation initiation repressor, eukaryo...
Figure 3 The chemical structures of 9 MEK inhibitors in clinical development.Nine MEK inhibitors are shown in the diagram. Among them, trametinib is being evaluated by FDA for treatment of advanced metastatic melanoma. Full size image Trametinib (GSK1120212, JTP 74057) Trametinib (GSK1120212, JTP-...
Gene ontology analysis revealed that trametinib upregulated the negative regulation of transcription by RNA polymerase and autophagy-related gene expression, but downregulated sensory perception of the chemical stimulus, positive regulation of neuron death and negative regulation of amyloid-beta clearance-...
AG1478 was from Wako Pure Chemical Industries (Osaka, Japan). MMP inhibitor II and MMP-2 inhibitor I were from Merck-Calbiochem (Darmstadt, Germany). Lipofectamine 2000 was from Invitrogen (Carlsbad, CA). All other reagents were of the highest grade of purity available. 2.2. Cell culture and...
a Chemical structure of erianin. b Cytotoxicity of erianin in normal NHEM and NHDF cell lines using MTT assay. c The left panel shows representative dose–response curves by MTT assay. The SK-MEL-2 (NRAS mut), HCT116 (KRAS mut), A375 (BRAF V600E), and SK-MEL-28 (BRAF V600E)...
These studies show that overexpressed novel PKC isoforms (δ, ε, and η) increase hINV protein and mRNA level, and hINV promoter activity, and that treatment with chemical inhibitors or dominant-negative PKC isoforms attenuates these responses (Efimova et al., 1998, 2002; Efimova and Eckert...
Sano, K., Y. Tsuda, H. Sugano, S. Aou, and A. Hatanaka, 2002, Concentration effects of green odor on event-related potential (P300) and pleasantness: Chemical Senses, v. 27, p. 225-230. Takehara-Nishiuchi, K., 2014, Entorhinal cortex and consolidated memory: Neurosci Res, v. 84...
H. et al. Combined chemical shift changes and amino acid specific chemical shift mapping of protein-protein interactions. J. Biomol. NMR 39, 275–289 (2007) Article CAS Google Scholar Download references Acknowledgements We thank L. Volpon, M. Osborne, G. Seabrook, and the Institute for ...