expose the acceptor of foul substance, acidify the new substrate with citric acid to deactivate the indole cycle necessary for tryptophanase by breaking it off and recombine DNA of intestine cyclic cells to form citric acid-unsaturated fatty acid cycle to remove foul smell and prevent infection.柏...
Why does a drug with a well-response for one patient, but not for the next, or in some cases, lead to serious adverse drug reactions (ADRs), namely individual variability in drug response (IVDR)? The answers are complicated and multi-faceted. First of all, therapeutic response rates of d...
et al. A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat. Biomed. Eng. 3, 520–531 (2019). Article CAS PubMed PubMed Central Google Scholar Cammarota, G. et al. Gut microbiome, big data and machine learning to promote precision medicine for cancer. Nat...
2,324,227名后代儿童的瑞典队列中,父母IBD与后代自闭症相关,且母亲的效应量大于父亲;② 连锁不平衡回归分析结果显示,未发现IBD与自闭症的遗传关联;③ 在包含7,348名母亲及7,503名后代儿童的队列中,母亲的IBD多基因风险评分(PRS)与后...
These are some of the procedures performed by Center for Digestive Medicine Colonoscopy A colonoscope is a flexible and steerable instrument to evaluate the entire colon (large intestine). The large intestine is approximately 3 – 4 feet long. A colonoscope is engineered such that biopsies of...
the burgeoning field of pharmacomicrobiomics aims to explore the correlation between microbiota variation and IVDR or ADRs. This review presents an up-to-date overview of the intricate interactions between gut microbiota and classical therapeutic agents for human systemic diseases, including cancer, cardio...
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The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Pedro Romero was the founding Section Editor.Page 1 of 10 The intricate interplay among microbiota, mucosal immunity, and viral infection in the respira...
infection, CCR9+CD4+T cells, which are effector cells derived from the lung, are recruited to the small intestine where they secrete Interferon-γ(Interferon-γ, IFN-γ). This leads to an imbalance in the gut microbiota that promotes Th17 cell polarization in the small intestine. Ultimately,...
side effects, such as oral sores,gastrointestinal diseases, hypertension,dyslipidemia, anemia, increased infection susceptibility, cancer, and systemic toxicity [77]. Therefore, encapsulation of pancreatic islets has emerged as a promising strategy to avoid the need for these immunosuppressant drugs [109]...