Orai channel–mediated Ca2+ influx is important in vasoconstriction, whereas BKCa is a Ca2+-activated potassium channel involved in the negative regulation of vasoconstriction. A mechanistic understanding of the potential interactions between BKCa and Orai channels in coronary artery spasm is lacking. ...
In a phase 2 clinical trial, an inhibitor of the KCa2 potassium channel, which conducts a repolarizing current in the heart, met the primary endpoint of promoting cardioversion from atrial fibrillation to sinus rhythm within 90 minutes of drug administration. ...
[41] found that Rhizoma Atractylodis Lanceae could inhibit the activity of sodium–potassium-ATPase, prevent the absorption of water and sodium ions, and thus to promote urination and excretion. Radix Achyranthis Bidentatae is sweet in flavor, has the function of reinforcing liver and kidneys,...
eTable 1. Median, interquartile range and sodium-potassium ratio of day-1, day-2 dietary recalls and the estimated usual intakes of sodium and potassium for total population and by gender, Third National Health and Nutrition Examination Survey Linked Mortality File 1988-2006. eTable 2. Adjusted...
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high-fat diet and 1% cinnamon extracts for 14 weeks, the body weight gain as well as the serum TC and TG were significantly reduced compared to the control [39]. Long-term high-fat dietary intake not only leads to dyslipidemia and weight gain, but also causes abnormal blood sugar and ...
(~500 mg) were digested with 10% potassium hydroxide for at least 3 days at 40 °C. Samples were then ultracentrifuged at 100,000gfor 4 h to generate a pellet enriched in solid materials resistant to such digestion, which included polymer-based solids10. A 1–2 mg portion ...
Overactive bladder (OAB) presents a high prevalence of 16–18% worldwide. The pathophysiology of OAB is still poorly understood while effective therapy or countermeasure are very limited. On the other hand, medicinal plants and herbal remedies have been utilized for treating lower urinary tract sym...
An approximately 70 year-old male with unknown medical history is brought to the emergency department with altered mental status. A community member contacted police after not seeing the patient for the past three days which was unusual. Upon entering the patient’s home, EMS found the patient ...