Concomitantly, astrocytes become reactive, endfeet become swollen and detached from vessels, phagocytic ability for Aβ is increased but neurotransmitter reuptake is decreased, and astrocytic secretions skewed to proinflammatory profiles with high levels of cytokines, chemokines, nitric oxide (NO), ROS, ...
13,14,50 High sodium levels induce increased blood pressure and hypertension by stiffening endothelial cells, thickening and narrowing resistance arteries, and blocking nitric oxide synthesis, whereas high potassium levels can counteract these effects by activating nitric oxide release.51 The opposite ...
It is noteworthy that the overall rate of death from any cause was numerically lower for patients who received QLQX than for those who received placebo, although this trend was not statistically significant (14.21% versus 16.85%). Both groups also demonstrated reduced serum NT-proBNP levels at ...
Cardiovascular disease (CVD) remains the predominant cause of mortality and disability worldwide. Against this backdrop, finding effective drugs for the pharmacological treatment of CVD has become one of the most urgent and challenging issues in medical
Recent micropuncture data have confirmed that the distal convoluted tubule plays a leading role in potassium secretion. Earlier concepts of a 1:1 exchange between sodium and potassium or hydrogen ion must be modified in light of recent findings. Plasma potassium levels may change the rate of renin...
In a phase 2 clinical trial, an inhibitor of the KCa2 potassium channel, which conducts a repolarizing current in the heart, met the primary endpoint of promoting cardioversion from atrial fibrillation to sinus rhythm within 90 minutes of drug administration. ...
Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation. 1998;98(12):1198-1204.PubMedGoogle ScholarCrossref 56. Walker RW, Lê KA, Davis J, et al. High rates of fructose malabsorption are associated with reduced liver fat in obese African ...
In some cases, the high levels of consanguinity may lead to certain challenges not anticipated when studying largely outbred cohorts. Among these are examples where it may be difficult to differentiate between driver and passenger mutations on a given haplotype. For example, two homozygous putatively...
#Hyperkalemia: Potassium 5.6, asymptomatic, AKI vs. medication-induced (aldactone). Continue monitoring. #AKI: Elevated creatinine 1.1 from baseline 0.7. Likely pre-renal given recent initiation of diuretics. Consider hepatorenal syndrome given decompensated cirrhosis. Follow-up repeat creatinine after 1L...
Participants were assessed for MASLD based on criteria and MD adherence measured by the Korean version of the Mediterranean-Diet Adherence Screener (K-MEDAS). Individuals were categorized into two groups based on their MD adherence: high adherence (K-MEDAS > 6) and low adherence (K-MEDAS...