Other evidence in support of the important role of GABA in controlling neuronal excitation comes from animal models wherein drugs (e.g. l-allylglycine) that block the GABA-synthesising enzyme glutamate decarboxylase or drugs that block GABAAreceptors (pentylenetetrazole) or GABA-activated Cl−channe...
Neuroactive steroids are a newer class of medicines that are thought to work by affecting levels of the neurotransmitter GABA in the body. Like NMDA receptor antagonists, they tend to work more quickly than most other antidepressants. [10] The FDA recently approved the following neuroactive steroids...
a chemical that nerves in the brain use to send messages to one another. GABA inhibits activity in many of the nerves of the brain, and it is thought
Benzodiazepines, which work by increasing the level ofgamma-aminobutyric acid, or GABA, a neurotransmitter that elicits a calming effect by reducing activity in the nervous system. This category includes the depressants Valium, Xanax and Ativan, among others. Antipsychotics, a class of drug that add...
Neurontin is not very potent for migraine, but it has so few side effects, that it may be worth a try anyway.This anticonvulsant is a prophylactic drug for treatment of migraine (Silberstein, 2000). Gabapentin (strangely enough) does not affect Gaba-b receptors or other commonly studied recep...
Gamma-hydroxybutyrate (GHB) drugs are central nervous system (CNS) depressants. Though their exact mechanism is not fully understood, they seem to affectgamma-aminobutyric acid (GABA)receptors in the brain during sleep, which may help regulate sleep and alertness. ...
However, the tide has turned with recent progress in biochemical engineering and the development of long-acting agonists at the receptor for glucagon-like peptide-1 (GLP-1), and with unimolecular peptides that simultaneously possess activity at the receptors for GLP-1, the glucose-dependent ...
Beta-blocking drugs work by blocking the receptors that are associated with some of the physiological symptoms of anxiety -- including rapid heartbeat. For what conditions are anxiety medications used? Anxiety medications are used either alone or in combination with psychotherapy to treat a number of...
It has been suggested that other broad-spectrum ASMs may also act partially through anti-glutamatergic activity. This is the case for FBM, which appears to inhibit NMDA receptors, and TPM, whose anti-kainate activity within the trigeminothalamic pathway may also play a role as an anti-migraine...
(2011), found no linear or curvilinear relationships between dopamine D1 receptor binding in dorsolateral prefrontal cortex and performance in any cognitive task, providing support for the notion that D1 receptors in separate brain regions are differentially related to performance in various cognitive ...