One of these medications is metformin, which has been linked with a rare but potentially serious side effect when taken by someone who has been drinking excessively. It increases the risk of lactic acidosis, which causes a buildup of lactic acid in the blood and could lead to such symptoms ...
Metformin is eliminated from the body via the kidneys in a process known as renal tubular secretion. Drugs that are also eliminated via this same pathway may compete with metformin for elimination when administered concomitantly and increase the risk of metformin-associated side effects due to an in...
In addition, insulin and its precursors may interact with liver cells to stimulate carcinogenesis (Adami et al, 1996). Because of the diabetes–liver cancer association, it has been suggested that anti-diabetic medication use could modify the risk. Metformin, a widely prescribed anti-diabetic drug...
The following medications decrease topiramate (Topamax) levels: phenytoin, carbamazepine, valproic acid, and lamotrigine. Using topiramate with acetazolamide or dichlorphenamide may increase the risk for kidney stones. Topiramate can interact with some drugs used fordiabetes(metformin, pioglitazone), so c...
Patients with T2D treated with metformin also had longer survival time than did age- and gender-matched, non-diabetic controls [64]. In this clinical trial named TAME (Targeting Aging with MEtformin), 3000 volunteers aged 70–80 years will be treated with metformin for 5–7 years to ...
The following medications decrease topiramate (Topamax) levels: phenytoin, carbamazepine, valproic acid, and lamotrigine. Using topiramate with acetazolamide or dichlorphenamide may increase the risk for kidney stones. Topiramate can interact with some drugs used fordiabetes(metformin, pioglitazone), so ...
Pre-treatment of monocytes with metformin strongly suppressed spike protein-mediated metabolic reprogramming that also suppresses inflammatory responses to SARS-CoV-2. This has potential implications for the treatment of hyper-inflammation during COVID-19 [201]. 7. Neutralizing Antibodies for SARS-CoV-2...
Using cultured rat hippocampal neurons, it was also shown that VPA protected against Aβ- and glutamate-induced neurotoxicity by decreasing the increase in intracellular free calcium levels. Similar results were also observed with phenytoin (PHT) and carbamazepine (CBZ) [41]. Based on this, it ...