There is considerable inter-individual variability in the response to metformin, and this has led to many drug鈥揹rug interaction (DDI) studies of metformin. In this review, we describe both invitro and human interaction studies of metformin both as a victim and as a perpetrator. We also ...
On the basis of the mechanisms of drug–drug interactions described previously, no interactions would be expected with a number of diabetes medications (metformin, glyburide, glitazones, canagliflozin, insulin), antihypertensives (diuretics, beta-blockers, angiotensin receptor blockers), cardiovascular ...
metformin methylprednisolone erythromycin labetalol Beta Blockers Oxycodone for Pain (OxyContin, Roxicodone, Oxecta, Oxaydo, Xtampza ER, Roxybond) hydrocodone/acetaminophen amiodarone, Cordarone, Nextrone, Pacerone hydrochlorothiazide cefuroxime bupropion celecoxib (Celebrex) codeine (for Pain) Levaquin (levofl...
UptakeIntestinal epithelium, hepatocyte, renal proximal tubule epithelial cellsCimetidine–metforminAUC andCmaxincreased (Burt et al., 2016) MDR/TAP Example, P-gpa EffluxIntestine, kidney, liver, brain, placenta 1. Clarithromycin–digoxin 2.
However, pharmacokinetic properties of metformin measured in rats were unchanged by the co-administration of oral or intravenous DA-9801. In conclusion, DA-9801 moderately inhibited transport activity of OCT1 and OCT2 but did not show significant in vivo drug–drug interaction potential with ...
Pharmacokinetic interaction between itraconazole and metformin in rats: competitive inhibition of metabolism of each drug by each other via hepatic and int... BACKGROUND AND PURPOSE Fungal infection is prevalent in patients with diabetes mellitus. Thus, we investigated whether a pharmacokinetic interaction...
interaction between genetic and external factors to develop precision medicine strategies that optimize drug therapy for individual patients. IVDR can also be attributed to the presence of variant alleles of drug-metabolizing enzymes, transporters, and targets in different populations.142,143,144Allelic ...
Metformin 129.16 12.4 −1.8 INS Basic Methotrimeprazine 328.47 9.19 4.84 NA Basic Mirtazapine 265.35 7.7 2.9 85 Neutral/Basic Naltrexone 341.4 8.38 2.07 21 Neutral/Acid Omeprazole 345.40 4.0 1.66 95 Basic Orlistat 495.74 15 7.61 >99 Neutral/Basic Propranolol 295.34 9.42 3.03 87 Acid Quetiapine ...
Phase 1 and Pharmacokinetic Drug-Drug Interaction Study of Metformin, Losartan, and Linagliptin Coadministered With DW1029M in Healthy Volunteers. We investigated botanical drug-pharmaceutical drug interactions between DW1029M (a botanical extract of Morus alba linne root bark and Puerariae radix) and....
Dolutegravir significantly increases metformin plasma exposure: one must not exceed metformin 500 mg twice daily with concomitant dolutegravir. Divalent or trivalent cations chelate dolutegravir. Therefore, concomitant administration of dolutegravir with aluminium- and calcium-containing antacids should be ...