Consequence of long-term high-dose use • Involuntary movements frequently involving the lips, tongue, jaw, face, trunk, and extremities • Discontinue offending antipsychotic medication • Consider switch to a lower risk antipsychotic QT prolongation • Rare but serious risk of sudden death ...
The QT interval represents the time required for ventricular tissue repolarization after ventricular depolarization. Medications may alter the QT interval, increasing the duration of repolarization and reducing the amplitude of the T wave, a state known asT-wave flattening.1To compensate for the importan...
Medication Pearl of the Day:Angiotensin II (Giapreza) Injection Indication:Angiotensin II (Giapreza) is a vasoconstrictor to increase blood pressure in adults with septic or other distributive shock. Insight: Dosing:Start angiotensin II intravenously at 20 nanograms (ng)/kg/min. Titrate as frequentl...
Reports on the survey conducted by the Sudden Arrhythmia Death Syndromes Foundation which revealed that psychiatrists and primary care physicians lack sufficient information for protecting patients against Long QT Syndrome, medication-induced heart disorder. Overview of the condition; People at risk of the...
ondansetron is administered incombination with other medications such as triptans and anxiolytics during an acute episode. Ondansetron is typically well-tolerated though headaches, drowsiness, diarrhea, and constipation have been reported. A baseline electrocardiogram (EKG) to check for QT prolongation is...
Cisapride, which is manufactured by Janssen Pharmaceutica, is approved for treating the symptoms of night time heartburn. The revised label states that 'QT prolongation, torsades de pointes (sometimes with syncope), cardiac arrest, and sudden death' have been reported in patients on cisapride who ...
"Receiving FDA approval of the first drug for the treatment of tardive dyskinesia is an important advance for patients with this condition. Our study is a valuable demonstration of its long-term safety, further validating the use of this medication," says Factor. ...
General considerations for perioperative medication management include a thorough medication history, understanding of the medication pharmacokinetics and potential for withdrawal symptoms, understanding the risks associated with the surgical procedure and the risks of medication discontinuatio...
October 4th 2024 FDA Grants Orphan Drug Designation to LQT-1213 to Treat Patients With Long QT Syndrome Luke Halpern, Assistant Editor October 4th 2024 Plozasiran May Help Reduce Cholesterol Levels in Patients With Mixed Hyperlipidemia Alexandra Gerlach, Associate EditorRecent...
Fortunately, resistance to these agents is still very low, and reserving them for use in populations at risk should preserve their effectiveness for some time. Be aware of the potential for complications with Clostridium difficile colitis, QT prolongation, and musculoskeletal damage from fluoroquinolones...