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Medical domain knowledge representations: a vocabularies and coding systems represented as lists or b hierarchies of codes, c ontologies as knowledge graphs, d rules as flowcharts, e sequential models as Markov models, f functions and probability distributions Full size image Previous integration of m...
The classification of a coding VUS should ultimately rely on the characterization of the protein’s function. Although, functional testing of an enzyme may be relatively straightforward, complex processes such as homologous recombination requires the assembly and concerted effort of several factors. As ...
DNA methylation-related long non-coding RNAs (DMlncRNAs) modulate gene expression by interacting with chromosomal modifications or remodeling factors, thereby affecting genomic instability and glioma progression. In lower grade gliomas (LGGs), specific DMlncRNAs have been identified as key regulators of ...
general mechanisms of sensory transduction and the broad organization of the central pathways in each of these sensory systems. In particular, note the similarity in transduction mechanisms for audition and vestibular sensation; and note the “logic” of sensory coding in the chemical sensory systems....
lncRNA long noncoding RNA LNK lymphocyte adaptor protein LOF loss of function LOH loss of heterozygosity LOX lipoxygenase LOX1 lectin-like oxLDL receptor 1 LP lumbar puncture; lymphocyte predominant Lp(a) lipoprotein(a) LPA lysophosphatidic acid LPC lysophosphophosphatidylcholine LPD lymphoproliferative ...
(which is often based on lectures) and introducing student-centered learning. The new formulation of medical education proposed by McMaster did not separate the basic sciences from the clinical sciences, and partially abandoned theoretical classes, which were taught after the presentation of the ...
These loss-of-function mutations have been grouped into two classes[168]. In class I, there is a total loss of KATP channels in the plasma membrane, resulting in no KATP current[51]. This type of mutation accounts for 10% of all diffuse CHI patients and 55% of focal CHI patients. ...
One limitation of the administrative data is the possibility of inaccurate coding; thus, these researchers carried out extensive sensitivity analyses using different OHIP codes and diagnosis codes. Second, all accuracy studies of PLA were performed in dermatology clinics. Due to a lack of data, ...