Tailored nanobiology and nanomaterials have been specifically designed to address the requirements related to tumors and inflammatory conditions, aiming to enhance or inhibit pyroptosis. Various methods involving favorable internal conditions such as the TME, physiological state, exosomes, and external ...
This phrase carried a nearly reverse meaning, i.e., to ‘quit a job without giving the employer proper notice,’ before developing its current figurative usage as a reference to the plight of a jilted lover. Sent away, with a flea in your ear; some girl has given you the bag. (John...
The precise role of specific microbes and metabolites is however unclear; likely due to the complex interplay between diet, microbiota and the host’s genetic background, meaning the optimal conditions may well be highly personalized. Prophylactic supplementation with certain “beneficial” bacterial ...
Hybridization, which may occur in many different spatial contexts, can impact both adaptation and speciation [5]. One such impact is adaptive introgression, where advantageous alleles are transmitted between different breeds [6,7], potentially assisting the development of new hybrid breeds with superior...
Human mesenchymal stem cells have attracted interest in regenerative medicine and are being tested in many clinical trials. In vitro expansion is necessary to provide clinical-grade quantities of mesenchymal stem cells; however, it has been reported to c
BMC Biology(2023) SARS-CoV-2 helicase might interfere with cellular nonsense-mediated RNA decay: insights from a bioinformatics study Behnia Akbari Ehsan Ahmadi Farshid Noorbakhsh BMC Genomic Data(2023) Functional consequences of C-terminal mutations in RUNX2 ...
The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations Article 29 June 2023 Data availability All data reported in this paper are available via figshare at https://doi.org/10.6084/m9.figshare.26236583.v1 (ref. 90). The sequencing ...
The results of the segmentation were further refined using proximity classifiers, meaning positive clusters within 20 μm were merged. This refinement step was necessary to help to get the total positive CD19, CD3 area per TLS. We defined TLS as >0.1 mm2 conglomerates of CD19+ B cells ...
First, membrane protein interactions can be protein-mediated, meaning that the two partner molecules make direct protein–protein contact, or interact via a third protein that holds them together. In this case, strong interactions, e.g., hydrogen bonds, ionic- and dipole-dipole interactions, can...
An explanation for why our c-fos and PNN effects appears largest in the CA1 may be that DG-CA3 connections are rather sparse compared with CA3-CA1 connections24,25,27, meaning in theory that a small change in population activity in the CA3 could have amplified downstream effects in the CA...