M42 proteins may mediate the pathologic effects of Aβ plaques through either gain or loss of function as a consequence of physical interactions with plaques—interactions which themselves may modulate the dynamics of plaque formation. APOE, which is the strongest common genetic risk factor for AD ...
Andersen (Life Science Editors) for comments on the manuscript; the staff at the IMP/IMBA in-house FACS facility, in particular G. Schmauss, and staff at the Molecular Biology Service. Deep sequencing was performed at the Vienna BioCenter Core Facilities. V.H. is supported by the Human ...
Peptide recognition modules mediate many protein-protein interactions critical for the assembly of macromolecular complexes. Complete genome sequences have revealed thousands of these domains, requiring improved methods for identifying their physiologically relevant binding partners. We have developed a strategy...
KIR2DS1-Positive NK Cells Mediate Alloresponse against the C2 HLA-KIR Ligand Group In Vitro The inhibitory 2DL1 and activating 2DS1 killer Ig-like receptors (KIR) both have shared ligand specificity for codon sequences in the C2 group HLA-Cw Ags. ... JH Chewning,CN Gudme,KC Hsu,... ...
The two tandem repeats are sufficient to mediate microtubule polymerization, and representative patient missense mutations lead to impaired polymerization both andas well as impaired microtubule stabilization. Furthermore, each repeat is predicted to have the secondary structure of a β-grasp superfold ...
This revealed a four-helix bundle-like configuration featuring terminal β-strands that can mediate higher order oligomerization. In solution, SPA17 forms both homodimers and tetramers and displays a weak affinity for AKAP18. Quantitative approaches reveal that AKAP18 binding occurs at nanomolar ...
Inter-organ communication is significantly increased in PDAC with specific organs as most frequent targets of exosomes communication occurring in health with the thymus, bone-marrow, brain, and intestines, and in PDAC with the kidneys, lungs and thymus. In sum, we find t...
Additionally, although both WIZ and CTCF contain zinc finger motifs, WIZ lacks the key residues that mediate CTCF binding to its consensus DNA sequence motif (Nakahashi et al., 2013). Specific aspects of how CTCF and WIZ interact remain to be investigated, including identifying the domains ...
CRISPR (clustered regularly interspaced short palindromic repeats) RNAs provide the specificity for noncoding RNA-guided adaptive immune defence systems in prokaryotes. CRISPR arrays consist of repeat sequences separated by specific spacer sequences. CRI
The goal of this study was to identify the site(s) in CR1 that mediate the dissociation of the C3 and C5 convertases. To that end, truncated derivatives of CR1 whose extracellular part is composed of 30 tandem repeating modules, termed c... M Krych-Goldberg,RE Hauhart,VB Subramanian,.....