甲基-CpG-结合蛋白质2基因表达目的探讨甲基结合蛋白MeCP2及去甲基化酶mbd2基因的表达异常在SLE发病中的作用. 方法以RT—PCR方法检测SLE缓解期,活动期患者与正常人外周血单一核细胞(PBMC)中MeCP2及mbd2基因的表达水平,并进行相关性分析.结果SLE活动期,缓解期及正常人对照组PBMC中MeCP2的表达差异无统计学意义(P...
9 MeCP2 has two well-characterized functional domains: the methyl-CpG-binding domain (MBD) that can bind selectively to DNA at symmetrically methylated CpGs10 and the transcription repression domain (TRD).11 DNA methylation is the major modification of eukaryote genomes and, in vertebrates, this ...
MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland. Oncogene. 2002;21:2704-12.Billard LM, Magdinier F, Lenoir GM, Frappart L, Dante R (2002) MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland. Oncogene 21:...
MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its association with oestrogen receptor status. Br J Cancer 2003; 89: 1934-1939Muller, H.M., Fiegl, H., Goebel, G., Hubalek, M.M., Widschwendter, A., Muller-Holzner, E., Marth, C. and Wid...
Heterologous expression of MECP2 with MBD defects does not affect Drosophila motoneuron dendrite development.Fernando, VonhoffAlison, WilliamsStefanie, RyglewskiCarsten, Duch
MECP2 missense mutations outside the canonical MBD and TRD domains in males with intellectual disability. J Hum Genet. 2016; 61:95-101.Bianciardi L, Fichera M, Failla P, Di Marco C, Grozeva D, Mencarelli MA, Spiga O, Mari F, Meloni I, Raymond L, Renieri A, Romano C, Ariani F...
and Cardoso,M.C. (2013) Direct homo- and hetero-interactions of MeCP2 and MBD2. PLoS One, 8, e53730.Becker A, Allmann L, Hofstatter M, Casa V, Weber P, Lehmkuhl A, Herce HD, Cardoso MC (2013) Direct Homo- and Hetero-Interactions of MeCP2 and MBD2. PLoS One 8:e53730....
Mapping of domains responsible for MeCP2 and MBD2 homo- and hetero-interactions.Annette BeckerLena AllmannMaria HofstätterValentina CasàPatrick WeberAnne LehmkuhlHenry D. HerceM. Cristina Cardoso
(2003). Methyl-CpG-DNA binding proteins in human prostate cancer: expression of CXXC sequence containing MBD1 and repression of MBD2 and MeCP2. Biochem Biophys Res Commun., 302, 759-766.Patra SK; Patra A; Zhao H;.Methyl-CpG-DNA binding proteins in human prostate cancer: expression of ...
Martin Caballero I, Hansen J, Leaford D, Pollard S, Hendrich BD (2009) The methyl-CpG binding proteins Mecp2, Mbd2 and Kaiso are dispensable for mouse embryogenesis, but play a redundant function in neural differentiation. PLoS One 4: e4315...