甲基-CpG-结合蛋白质2基因表达目的探讨甲基结合蛋白MeCP2及去甲基化酶mbd2基因的表达异常在SLE发病中的作用. 方法以RT—PCR方法检测SLE缓解期,活动期患者与正常人外周血单一核细胞(PBMC)中MeCP2及mbd2基因的表达水平,并进行相关性分析.结果SLE活动期,缓解期及正常人对照组PBMC中MeCP2的表达差异无统计学意义(P...
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结论 在正常情况下,MeCP2和mbd2的表达相互制约,在SLE患者中这种关系被破坏。 关键词: 系统性红斑浪疮, MeCP2, mbd2; Abstract: Objective To investigate the gene expression of methyl-CpG-binding protein 2 (MeCP2) and methyl-CpG-binding domain 2 (mbd2) in patients with systemic lupus ...
9 MeCP2 has two well-characterized functional domains: the methyl-CpG-binding domain (MBD) that can bind selectively to DNA at symmetrically methylated CpGs10 and the transcription repression domain (TRD).11 DNA methylation is the major modification of eukaryote genomes and, in vertebrates, this ...
Focuses on a study which investigated in human tissues the expression of the methyl binding proteins MeCP2 and MBD2 during the proliferation of normal breast and in benign and neoplastic breast tumors. Results; Discussion; Materials and methods.Billard, Lisa-Marie...
MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland. Oncogene 2002; 21(17): 2704-12.Billard LM, Magdinier F, Lenoir GM, Frappart L, Dante R.MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland. Oncogene 2002;...
MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its association with oestrogen receptor status. Br J Cancer. 2003;89:1934-9.Muller HM,Fiegl H,Goebel G, et al.MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its ...
and Cardoso,M.C. (2013) Direct homo- and hetero-interactions of MeCP2 and MBD2. PLoS One, 8, e53730.Becker A, Allmann L, Hofstatter M, Casa V, Weber P, Lehmkuhl A, Herce HD, Cardoso MC (2013) Direct Homo- and Hetero-Interactions of MeCP2 and MBD2. PLoS One 8:e53730....
The methyl-CpG-binding domain (MBD) gene family was first linked to autism over a decade ago when Rett syndrome, which falls under the umbrella of autism spectrum disorders (ASDs), was revealed to be predominantly caused by MECP2 mutations. Since that time, MECP2 alterations have been ...
Heterologous expression of MECP2 with MBD defects does not affect Drosophila motoneuron dendrite development.Fernando, VonhoffAlison, WilliamsStefanie, RyglewskiCarsten, Duch