目前MECP2导致自闭症社交障碍的神经环路成因尚未明确,为了在体观察自闭症模型MECP2-TG小鼠的神经活动,我们在MECP2-TG小鼠和野生型小鼠海马CA1区域分别注射腺相关病毒包装的钙示踪荧光蛋白(GCaMP6s),然后使用一套微型内置显微镜观察小鼠在三厢实验中活动时海马CA1区域神经细胞的发放.我们发现在野生型小鼠海马CA1中...
Another chapter in the MECP2 story: Exon 1 mutation in a male child (c.62+262+3delTG)We describe the clinical presentation of MECP2 exon 1 mutation, a rare cause (1-3%) of classical Rett syndrome in female children, not reported before in a male child (named Scott), including ...
人类男性中MECP2基因的倍增将导致严重的自闭症症状.过表达人源MECP2基因,会使转基因小鼠(MECP2-TG)表现出类似自闭症的行为,但这种社交行为缺陷相关的神经环路机制尚不明确.本文在小鼠海马体CA1区植入微型荧光透镜,观察MECP2-TG小鼠和野生型小鼠的社交过程... 孙乐,陈睿国,李龙,... - 《Science Bulletin》 ...