This chapter focuses on the mechanism of synaptic excitation. Before leaving the spinal cord via the ventral root, axons of the motoneurons send axon collaterals to make synapses with the small interneurons situated in the medial part of the ventral horn. This interneuron was discovered by Renshaw...
There is a tiny space, the synaptic cleft, between the presynaptic and postsynaptic structures, so they are not in physical contact. In neuron-to-neuron synaptic transmission, when a nerve impulse reaches the terminal bouton of the presynaptic neuron, it causes the terminal bouton to secrete ...
The properties of exosomes are also beginning to entice the biomedical community since they represent potentially novel avenues for the targeted delivery of customized exosome cargo, such as miRNAs, during disease. Our findings implicating exosomes in trans-synaptic communication emerged from the ...
Overviews of presynaptic neurotransmitter release, mechanisms of presynaptically mediated short- and long-term plasticity, and the role of presynaptic plasticity in learning and memory are provided. This is followed by individual examples of presynaptic molecules and their potential link to synaptic ...
The strand-exchange reaction is central to homologous recombination. It is catalysed by the RecA family of ATPases, which form a helical filament with single-stranded DNA (ssDNA) and ATP. This filament binds to a donor double-stranded DNA (dsDNA) to form
SYNAPTIC transmission in the hippocampus is rather unreliable, with many presynaptic action potentials failing to release neurotransmitter1–4. How is this unreliability affected by the alterations in synaptic strength seen in long-term potentiation (LTP
[8] investigated the effect of Anle138b on amyloid-β channels for rescuing AD disease phenotypes in an amyloid mouse model, showing that it blocks these conducting channels in neuronal membranes, which could be linked to restoration of synaptic plasticity and memory function in vivo. Dominguez-...
[38]. Sustained pathological neuroinflammation can lead to various detrimental effects, including peripheral immune cell infiltration, increased permeability and breakdown of the blood–brain barrier (BBB), demyelination, synaptic loss, and neuronal death. Neuroinflammation is commonly observed in conditions ...
Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networksmouseneuroscienceAmyotrophic lateral sclerosis (ALS) is a... P Branchereau,E Martin,L Supiot,... - 《Elife Sciences》 被引量: 0发表: 2019年 Differentiation of dementia with Lewy bodies from Alz...
Whether synaptic vesicles (SVs) are recovered via endosome-mediated pathways is a matter of debate; however, recent evidence suggests that clathrin-independent bulk endocytosis (CIE) via endosomes is functional and preferentially replenishes SV pools during strong stimulation. Here, using brefeldin-A (...