first time how an FW domain mediates protein-protein interaction. Combined with mutational analysis, we show that a conserved pocket of the FW domain specifically recognizes the N-terminal di-glycine of CtAms1. Our findings have implications for understanding the general binding mode of FW domains...
the glycan component; no mechanism of protein specificity by this class of enzymes has yet been described. The Asn297-linkedN-glycan is required for IgG binding to Fc γ receptors (FcγRs) and complement C1q, which trigger antibody-mediated effector functions5,6,7,8. The activity of these ...
Conformational preferences of π–π stacking between ligand and protein, analysis derived from crystal structure data geometric preference of π–π interaction. Interdiscip. Sci. 7, 211–220 (2015). Article CAS PubMed Google Scholar Jiang, L. et al. Structure-based discovery of fiber-binding ...
lipids from the LNP surface, 2) binding of distinct proteins to the nanoparticle surface because of recognition of exposed SORT molecules, and 3) subsequent interactions between surface-bound proteins and cognatereceptorshighly expressed in specific tissues. These findings establish a crucial link between...
Polyphenols, which are some of the most popular antioxidants and antimicrobials, have been widely used in freshwater fish preservation and storage to prevent protein degradation. However, their binding behavior and mechanism is still unclear. In this study, the binding mechanisms of two types of ...
protein (YAP) and transcriptional co-activator with PDZ binding motif protein to translocate into the nucleus, thereby regulating various biological effects. In addition, YAP, as a major effector molecule of Hippo signaling pathway, is aberrantly expressed in many tumors and is closely related to ...
The docking results of resveratrol with OSCC molecules indicated that key targets, such as EGFR, ESR1, and SRC, have good binding activity. The results of cell-based experiments showed that resveratrol inhibited the protein expression of SRC, EGFR, ESR1, p-PI3K, and p-AKT in HSC-3 cells ...
the glycan component; no mechanism of protein specificity by this class of enzymes has yet been described. The Asn297-linkedN-glycan is required for IgG binding to Fc γ receptors (FcγRs) and complement C1q, which trigger antibody-mediated effector functions5,6,7,8. The activity of these...
GPRC5D is an atypical Class C orphan G protein-coupled receptor. Its high expression on the surface of multiple myeloma cells has rendered it an attractive target for therapeutic interventions, including monoclonal antibodies, CAR-T cells, and T-cell engagers. Despite its therapeutic potential, the...
of HER2 protein [69]. GP2 is another peptide vaccine that targets HLA-A2-restricted nonapeptide based on the transmembrane domain of the HER2 protein [70]. Moreover, the AE37 vaccine is a 12-mer peptide that targets the intracellular domain of modified HER2 [71]. Four amino acids ...