The myofibrils of skeletal muscle contain abundant mitochondria, which are important parts of the TCA cycle. It is a productive semiautonomous organelle that produces large amounts of ATP, which provides energy for muscle contraction and relaxation. In many diseases involving muscle lesions, such as...
Inhibition of cholinergic signaling pathways in OABIn the cholinergic pathway [33,34,35], acetylcholine is a contractile neurotransmitter released by the sacral medullary parasympathetic post-ganglia fibers, which promotes detrusor contraction by mediating M receptor. M-Acetylcholine receptors can be divided...
The sequence alignment was done using MUSCLE v13 [51]. The PROTGAMMAILGF model was selected by ProtTest v. 3.4 [52]. A maximum likelihood (ML) phylogenomic tree was built using the 631 concatenated amino acid sequences with RAxML v. 8 [53]. Trees were figured in Tree v. 1.4.2 [54...
When the heart beats, the blood flow from the heart exerts a pressure on the blood vessels. BP varies between systolic BP (SBP), which is an increase in pressure caused by systolic contraction of the heart, and diastolic BP (DBP), which is the low pressure between SBPs. High BP (...
but the precise effects of lumican on re-epithelialization and wound contraction have not yet been fully understood. For instance, it is reported that lumican can promote skin wound healing by facilitating wound fibroblast activation and contraction but not by promoting keratinocyte proliferation and ...
overrepresented were hemostasis, complement cascade, inflammation mediated by the chemokine and cytokine signaling pathway, integrin cell surface interaction, signaling in the immune system, plasminogen activation cascade, cardiac muscle contraction, cardiomyopathy, and metabolism of lipids and lipoproteins (...
The present study aimed to investigate the acute effects and the mechanism of ketamine on nicotine-induced relaxation of the corpus cavernosum (CC) in mice. This study measured the intra-cavernosal pressure (ICP) of male C57BL/6 mice and the CC muscle activities using an organ bath wire myogr...