insulin actioninsulin receptor substratesinsulin receptorsinsulin resistanceIRS1IRS2pancreatic β cellsphosphatasesPI3KInsulin and IGF (insulin-like growth factor) signaling integrates the storage and release of nutrients with animal growth during development and throughout adult life. It is essential for ...
The Molecular Mechanism of Insulin Action Insulin initiates its action by binding to a glycoprotein receptor on the surface of the cell. This receptor consists of an alpha-subunit, which binds the ... Kahn,C R - 《Annual Review of Medicine》 被引量: 668发表: 1985年 Insulin Receptors, ...
There are some phenomena to support our opinion that the field of insulin action is located intracellularly, and is concerned with energy generation, including mitochondria. In the experiments, the measurements of mitochondrial swelling were carried out by following the optical density of that suspension...
A., 1974, Nerve growth factor and insulin: Evidence of similarities in structure, function and mechanism of action, Rec. Prog. Horm. Res. 30 : 575.Bradshaw, RA, Hogue-Angeletti, RA, Frazier, WA (1974) Nerve growth factor and insulin: Evidence of similarities in structure, function and ...
The inflammasomes are innate immune system receptors and sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins. They have been implicated in a host of inflamm
(i) Insulin has an immediate physical action on the cell/extracellular interface, altering the redox potential gradient (electron conductance) across the plasma membrane. (ii) Conversely, the formation of an insulin-membrane complex depends, among other factors, on the prevailing trans-membrane redox...
One of the important metabolic effects of insulin is its ability to stimulate the synthesis of glycogen in skeletal muscle within minutes; much research has been directed toward understanding the molecular basis of this effect. Almost 25 years ago, Joseph Larner and co-workers showed that glycogen...
Combining the different approaches, we found evidence supporting the hypothesis that the action of Anle138b involves several processes which are key to AD progression, including cholesterol homeostasis and neuroinflammation. On the pathway level, we found significantly enriched pathways related to these ...
measurements. The interpretation of the results obtained is consistent with the data of previously performed structural studies of the action of HD proteins on the conformation of IFN-γ7, and for the first time explains the physical features of the molecular mechanism of the modifying action of ...
The mechanism by which the specific β-adrenoceptor agonist AJ-9677 relieves insulin resistance in vivo was investigated by studying its effects in the white and brown adipose tissues of the KK-A~y/Ta diabetic obese mouse model. AJ-9677 reduced the total weight of white adipose tissues by redu...