DNA replication is demonstrated to remove ectopically loaded, non-centromeric CENP-A. In contrast, tethering of centromeric CENP-A to the sites of DNA replication through the constitutive centromere associated network (CCAN) is shown to enable precise reloading of centromere-bound CENP-A onto the ...
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 20, 845–854 (2005). Article CAS PubMed Google Scholar Nishiyama, A. et al. Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nature 502, 249–253 (2013). Article ...
The peptide antibiotic albicidin is a DNA topoisomerase inhibitor with low-nanomolar bactericidal activity towards fluoroquinolone-resistant Gram-negative pathogens. However, its mode of action is poorly understood. We determined a 2.6 Å resolution
Our study examines the mechanisms by which DNA polymerase (pol) δ faithfully replicates DNA. To better understand this process, we have performed all-
The KEGG enrichment analysis indicated “Starch and sucrose metabolism” and “DNA replication proteins” were the common enriched pathways at all S treatment time-points. The main enriched KEGG pathways among the DEGs on day 1 of the S treatment were “Transcription factors,”“Plant hormone signa...
The human TNF gene is a 7 kb DNA sequence that encodes TNF-α and TNF-β (Huang et al. 2020). TNF-α is a pleiotropic pro-inflammatory cytokine that plays a crucial role in various diseases, including hypertension (Granger 2006). Heightened concentrations of TNF are associated with augmente...
From these sequences, the longest open reading frames were extracted and translated into protein sequences for the subsequent construction of evolutionary trees. The neighbor-joining phylogenetic tree was constructed using MEGA X software, and the process involved performing 1000 bootstrap replications ...
It associates with promoters of hundreds of genes involved in every essential process including transcription, translation, DNA replication, repair, recombination, transport and metabolism of nucleotides, amino acids, lipids, carbohydrates and cofactors, cell wall synthesis, cell division and others (...
Our data suggest a mechanism of Gabija immunity: the nuclease activity of Gabija complex is inhibited under physiological conditions, while it is activated by depletion of NTP and dNTP upon the replication and transcription of invading phages and cleave the circular DNA to prevent phage DNA ...
The formation of clustered mutations may result from the process of DNA repair. Anna Malkova, associate professor of biology in the UI College of Liberal Arts and Sciences, notes that the DNA repair pathway, known as break-induced replication (BIR), can promote clusters of DNA mutations. "Prev...