The article describes the use of blended care as a mechanism of action in the construction of a therapy that uses digital means to improve and support current clinical treatments. The so-called digital therapeutics provides evidence-based therapeutic interventions ...
Efficacy of a digital therapeutics system in the management of essential hypertension: the HERB-DH1 pivotal trial. Eur Heart J. 2021;42:4111–22. Article PubMed PubMed Central Google Scholar Kibble M, et al. Network pharmacology applications to map the unexplored target space and therapeutic ...
The ECL2 of the currently known class C GPCRs interacts primarily with the elongated stalk–referred to as the cysteine-rich domain (CRD)–in mGlu and CaSR (linking the VFT to the TMD) and forms a disulfide bond with the cysteine of TM317,22,26. However, the N-terminus of most clas...
Finally, the sections were scanned utilizing a Panoramic Digital Section Scanner (VS120) (Olympus, Japan). 2.5 Isolation of pulmonary tissue cells and flow cytometry To minimize hemorrhaging and facilitate exposure of the heart, the thoracic cavity of the mice was carefully opened using scissors. ...
of GPCRs in that they only function as obligatory homo- or heterodimers rather than as monomers12,13,14,15. The structures of class C GPCRs solved to date all share a large and varying Venus Flytrap (VFT) extracellular domain for ligand-binding, binding of which transduces conformational ...
Treatment of Tinea pedis of the interdigital •••••••••••• •••••••• •••• Treatment of Vulvovaginal mycotic infection •••••••••••• Treatment of Cutaneous candidiasis •••••••••...
Noisy Intermediate-Scale Quantum (NISQ) technology will be available in the near future. Quantum computers with 50-100 qubits may be able to perform tasks which surpass the capabilities of today's classical digital computers, but noise in quantum gates will limit the size of quantum circuits that...
Chronic refractory wounds easily relapse and seriously affect the patients’ quality of life. Previous studies have shown that stromal vascular fraction gel (SVF-gel) significantly promotes the early healing of chronic wounds; however, the mechanisms of
We wish to extend our thanks to the following individuals: D. Bosco and T. Berney, University of Geneva, and L. Piemonti, San Raffaele Scientific Institute, Milan, for human islets through ECIT; C. Mathews, University of Florida, and R. Bottino, Institute of Cellular Therapeutics, Allegheny...
Structural analysis of Gn complexed with four Gn-specific monoclonal antibodies resulted in the definition of three antigenic patches (A, B and C) on Gn domain I. Both patches A and B are major neutralizing epitopes. Our results highlight the potential of antibody-based therapeutics and provide...