Using a model ofP. yoelii nigeriensisN67C (N67C) infection in C57BL/6 mice, we previously showed that the host mounts a vigorous innate immune response, with massive loss of red pulp splenic cells by day 4 post-infection (p.i.)37,38. The early death of infected mice at relatively l...
Mechanism of cell death induced by magnetic hyperthermia with nanoparticles of γ-MnxFe2−xO3 synthesized by a single st... Magnetic nanoparticles of γ-MnxFe2−xO3 (0 ≤x≤ 1.3) have been synthesized successfully using a single step process wh... N.,K.,Prasad,... - 《Journal of ...
Cells from medulloblastoma lines do not contain detectable amounts of the basic leucine-zipper protein Zhangfei. However, we have previously shown that exp
G. et al. Bacterial gasdermins reveal an ancient mechanism of cell death. Science 375, 221–225 (2022). Article ADS CAS PubMed PubMed Central Google Scholar Kibby, E. M. et al. Bacterial NLR-related proteins protect against phage. Cell 186, 2410–2424.e18 (2023). Article CAS PubMed...
Depletion of glutathione rendered the HL-60 cells highly sensitive to cell death induced by H2O2, an effect that was not mediated by changes in the activities of glutathione reductase, glutathione peroxidase, catalase, or superoxide dismutase. The increased sensitivity to oxidative stress was largely ...
In multicellular organisms, regulatory cell death is a crucial aspect of growth and development. Ferroptosis, which was postulated roughly ten years ago, is a mode of cell death that differs from apoptosis, autophagy, and pyrodeath. This distinct pattern
The genome, essential for all organisms, is threatened by many external and internal factors, which cause thousands of DNA damage events in each cell every day. Some damages could be so severe as to cause harmful mutations and cell death. So during evolution, the living cell developed sophistic...
Treatment and rehabilitation of spinal cord injury (SCI) is a major problem in clinical medicine. Modern medicine has achieved minimal progress in improving the functions of injured nerves in patients with SCI, mainly due to the complex pathophysiologica
Necroptosis is an important mode of cell death, which is due to oxidant stress accumulation. Our previous study indicated that oxidant stresses could be reduced by Timosaponin B-II (TBII), a kind of Chinese herb RhizomaAnemarrhenae monomer extraction. We
To explore the molecular network mechanism of Celastrol in the treatment of rheumatoid arthritis (RA) based on a novel strategy (integrated systems pharmacology, proteomics, transcriptomics and single-cell transcriptomics). Firstly, the potential targets