The cellular mechanism of action of sulfonylureas may vary depending upon the exact nature of the drug, the tissue or cell type in question, and the status of the subject from which it was obtained. In adipocytes from patients with type II non-insulin-dependent diabetes, there is increasing ...
The diarylsulfonylureas (DSU's) represent a novel class of antitumor agents that were identified as active against rodent solid tumors, but not against leukemias [1, 2]. We subsequently demonstrated activity against human tumor xenografts [3] and notably against xenografts from colon adenocarcinomas ...
A. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29, 254–258 (2006). PubMed Google Scholar Farooqi, I. S. et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction...
Acetohexamide has one-third the potency of chlorpropamide, and twice the potency of tolbutamide; however, similar hypoglycemic efficacy occurs with equipotent dosage of sulfonylureas. Mechanism of action Sulfonylureas such as acetohexamide bind to an ATP-dependent K+ channel on the cell membrane ...
When initiating Ozempic®, consider reducing the dose of concomitantly administered insulin secretagogue (such as sulfonylureas) or insulin to reduce the risk of hypoglycemia Ozempic®causes a delay of gastric emptying and has the potential to impact the absorption of concomitantly administered oral ...
mechanism of actionMost antihyperglycemic agents available for the treatment of type 2 diabetes mellitus (T2DM) have insulin-dependent mechanisms of action; that is, they either stimulate insulin production (sulfonylureas, glinides, incretin mimetics, dipeptidyl peptidase-4 inhibitors), improve insulin ...
Mechanisms of acute and chronic hypoglycemic action of gliclazide An extrapancreatic effect of sulfonylureas has been postulated. However, in vivo results have been disputed because the amelioration of insulin action that... VD Tos,A Maran,SVD Kreutzenberg,... - 《Acta Diabetologica》 被引量: ...
The impact of ATP-sensitive K+ channel subtype selectivity of insulin secretagogues for the coronary vasculature and the myocardium Insulin secretagogues (sulfonylureas and glinides) increase insulin secretion by closing the ATP-sensitive K+ channel (KATP channel) in the pancreatic beta... U Quast...
A-type current has an important role in the early repolarization phase of action potentials (10, 43). 4-AP potentiates insulin secretion from rat islets and insulinoma cells stimulated by sulfonylureas, even in the absence of glucose (5). Therefore, it is reasonable to predict that the down-...
The mechanism of action of tolbutamide. Observations on the effects of sulfonylureas on peripheral metabolism in man In this paper we review a number of analytical mothods and issues related to identifying and estimating the source of productivy growth. W. J. H. Butterfield,M. M. H. Arab,A...