Mechanisms of action of SSRI's in depressive patients with cardiac disorders are associated with their ability to reduce inflammation, platelet, and endothelial dysfunction. This review focuses on the potential pathophysiological and psychosocial links between cardiac diseases and depression, the treatment ...
Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI).2 It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathol...
In recent years, however, the credibility of the monoamine theory and the therapeutic efficacy of these compounds in the treatment of depression has been extensively criticized. In the current review the legitimacy of these criticisms is critically examined, in many instances the evidence base used ...
Fluoxetine: a case history of its discovery and preclinical development Since its discovery, other molecules that mimic its mechanism of action have been developed, commencing a new age in the treatment of depression. ... L Perez-Caballero,S Torres-Sanchez,L Bravo,... - 《Expert Opinion on ...
in this trial. For those not previously receiving SSRIs, the dose was adjusted to the recommended level. If poor tolerance to the initial SSRI occurred, the psychiatrist adjusted the prescription according to the medication protocol, switching to an alternative SSRI before inclusion. The particip...
LSD’s remarkable potency led psychiatrists to speculate about the existence of an endogenous LSD-like “schizotoxin” in the brain of patients with schizophrenia [11]. This review attempts to summarize research on the mechanism of action of LSD-induced psychosis. 1.2. Psychosis and LSD: Human ...
Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an...
This review provides a brief summary of what is known about the anxiolytic mechanism of action of pregabalin, a highly selective, high-affinity ligand of t
These results support further investigation of mGluR2/3 and other glutamate-targeted treatments for schizophrenia.Similar content being viewed by others A randomized placebo-controlled PET study of ketamine´s effect on serotonin1B receptor binding in patients with SSRI-resistant depression Article ...
Results: The PSP administration remarkably shortened the immobility time of the behavioral despair model mice both in tail suspension test and forced swimming test (P<0.05), showing the antidepressant activity. At the same time, PSP had no influence on the body weight and locomotor activity of ...