Mechanism of action of antidepressants. Artigas Francesc,Nutt David J,Shelton Richard. Psychopharmacology Bulletin . 2002Artigas, F., Nutt, D.J. and Shelton, R. (2002) Mechanism of action of antidepressants. Psychopharmacol. Bull., 36(Suppl. 2): 123-132....
However, it is not yet known which 5-HT receptor subtypes mediate the therapeutic effects of antidepressants. Methods The effects of the SSRI, paroxetine and the SNRI, venlafaxine were evaluated in the mouse four plates test (FPT). Results Paroxetine administered intraperitoneally (IP) (0.5, 2鈥...
Of the antidepressants evaluated, the authors found that there were significant differences in the relative potency of each of the compounds, with fluoxetine significantly more potent than citalopram. This same group Anti-inflammatory effects of non-SSRI antidepressants While the anti-inflammatory effects...
Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI).2 It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathol...
In addition to its tolerability, citalopram is effective in the treatment of major depression, other depressive disorders and panic disorder. It has the ... K Bezchlibnyk-Butler,I Aleksic,SH Kennedy - 《J Psychiatry Neurosci》 被引量: 191发表: 2000年 The importance of new antidepressants in...
with as much stimulation as could be tolerated, while patients in the SIA group were not pressed. What’s more, patients did not receive any other antidepressants beyond SSRIs, but temporary administration of sedative-hypnotics was allowed if necessary, and all patients were instructed to keep me...
18.Field-Free Orientation of Linear Molecules by Using Double Half-Cycle Pulses;线型分子在双半圈激光脉冲作用下的过场取向 相关短句/例句 dual-acting mechanism双重作用机制 1.SSRI\'plus\' is mainly focused on designing antidepressants with dual-acting mechanism of SSRI/5-HT_(1A) and SSRI/NRI.研究...
Unfortunately, the onset of action of SSRIs is often delayed by 3–6 weeks (Artigas, 2013). The existence of this delayed action combined with the fact that one-third of patients do not respond to treatment emphasizes the need for faster acting and more effective antidepressants (Samuels et ...
from those of existing antidepressants. The studies about the mechanism of pharmacologi- cal action of venlafaxine mostly investigated the effects of venlafaxine on 5-hydroxytryptamine (5-HT), norepinephrine (NE) and dopamine (DA) levels, while only few studies examined the ef- ...
This review provides a brief summary of what is known about the anxiolytic mechanism of action of pregabalin, a highly selective, high-affinity ligand of t