Irinotecan is a strong anticancer drug whose mechanism of action has been reported only for the inhibition of DNA topoisomerase I (Topo I) through its active metabolite SN-38. In this study, we present a new mechanism of Irinotecan which inhibits the activities of MDM2, an E3 ligase of ...
Irinotecan The metabolism of Irinotecan can be decreased when combined with Rilpivirine. Isavuconazole The serum concentration of Rilpivirine can be increased when it is combined with Isavuconazole. Isavuconazonium The serum concentration of Rilpivirine can be decreased when it is combined with Isavuco...
Irinotecan, sold under the brand name Camptosar among others, is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to ...
Irinotecan The metabolism of Irinotecan can be decreased when combined with Tramadol. Isavuconazole The metabolism of Tramadol can be decreased when combined with Isavuconazole. Isavuconazonium The metabolism of Tramadol can be decreased when combined with Isavuconazonium. Isocarboxazid The risk or ...
Complete response of highly advanced colon cancer with multiple lymph node metastases to irinotecan combined with UFT: report of a case. Massive lymph node metastasis of the para-aortic region and supraclavicular lymph nodes, Virchow's lymph node metastasis due to colon cancer, is extremely ... ...
The topoisomerase I (Top 1) poison irinotecan is an important component of the modern treatment of colorectal cancer. By stabilising Top 1-DNA complexes, i... DC Gilbert,AJ Chalmers,SF El-Khamisy - 《British Journal of Cancer》 被引量: 103发表: 2012年 Pharmacogenomic Identification of Targets...
Ou-gon, an extract from Scutellaria baicalensis Georgi root, has been shown to exhibit pronounced antifungal activity. The present study aimed to identify antifungal components of Ou-gon and to determine their mechanism of action against pathogenic fungi
Irinotecan The serum concentration of Irinotecan can be increased when it is combined with Cannabidiol. Isavuconazole The metabolism of Cannabidiol can be decreased when combined with Isavuconazole. Isavuconazonium The metabolism of Cannabidiol can be decreased when combined with Isavuconazonium. Isocarb...
Yet, the underlying mechanisms of its action remain largely unknown. The research presented in this thesis focused on elucidating the mechanism of safingol and its potential to synergize with conventional anti-cancer drugs. It is demonstrated that safingol/irinotecan combination was synergistic in ...
The Effect and The Synergistic Mechanism of Irinotecan Combined With Norcantharidin in Human Gastric Cancer Cell Line BGC-823 To investigate the proliferative effects and the synergistic mechanism of irinotecan combined with norcantharidin in human gastric cancer cell line BGC-823. BGC-823 cells were tr...