In particular, we will focus on (1) new chemical scaffolds and structure–activity relationships; (2) their binding mode with Top1–DNA binary complex; (3) new natural product derivatives with improved pharmacological and pharmacodynamic profiles (eg, evodiamines, indolocarbazoles, lamellarins, ...
acquisitionwas performedintheselectedionmonitoringmode.Recoverieswere69and47%onaverage,detectionlimits2.5and0.25 ng/mlandquantitationlimits10and0.5ng/mlforirinotecanandSN-38,respectively.Reproducibilitywasgoodandthe methodwaslinearfromlimitsofquantitationupto10000ng/mlforirinotecan,andupto100ng/mlforSN-38.This ...
drug resistance challenge as they are not recognized by the p-glycoprotein transporter [4]. Therefore, IRH is considered as a favorable chemotherapy which, unlike the majority of chemotherapy agents, does not rely on the O(6)-Methylguanine-DNA methyltransferase (MGMT) methylation mode of action [...