Virology Mechanism of action of allosteric HIV-1 integrase inhibitors THE OHIO STATE UNIVERSITY Mamuka Kvaratskhelia SlaughterAlison PaigeAn essential step in the HIV-1 replication cycle is the integration of the viral DNA into the host chromatin, which is catalyzed by the viral enzyme integrase (...
Mechanism of action Like other HIV protease inhibitors, tipranavir binds to the active site of the HIV protease enzyme, thereby preventing processing of viral encoded Gag and Gag–Pol polyproteins necessary for the formation of mature, infectious viral particles. Tipranavir binding to the HIV-1...
Structural basis of HIV-1 maturation inhibitor binding and activity HIV maturation inhibitors such as bevirimat (BVM) interfering with Gag processing are emerging as alternative anti-retroviral drug candidates. Here, the authors report structures of assemblies of HIV-1 Gag fragments spanning the CA C...
Figure 1 Mechanism of action of caplacizumab Pathologic von Willebrand factor degradation with a left ventricular assist device occurs via two distinct mechanisms: Mechanical demolition and enzymatic.
Temorelin is indicated for the treatment of excess abdominal fat in HIV-infected patients with lipodystrophy and is not indicated for weight loss management (weight neutral effect). Fig. 1 Characteristics of Tesamorelin (usan) Mechanism of Action Temorelin is a synthetic analog of growth hor...
The HIV-1 gp41 (glycoprotein 41) core plays a critical role in fusion between the viral and target cell membranes. We previously identified a gp41 core-binding motif, HXXNPF, by screening the phage display peptide libraries. In the present study, we elucidated the mechanism of action of H...
4 Terminated Treatment HIV-associated Myelopathy 1 somestatus stop reason just information to hide 4 Unknown Status Treatment Aspergers Syndrome / Autism Disorder / Pervasive Development Disorder 1 somestatus stop reason just information to hide 4 Unknown Status Treatment Chronic Inflammatory Demyelinating ...
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a very promising new class of anti-HIV-1 agents that exhibit a multimodal mechanism of action by allosterically modulating IN multimerization and interfering with IN-lens epithelium-derived growth factor (LEDGF)/p75 binding. Selection of vi...
Mechanism of action The primary mechanism of action of amikacin is the same as that for all aminoglycosides. It binds to bacterial 30S ribosomal subunits and interferes with mRNA binding and tRNA acceptor sites, interfering with bacterial growth. This leads to disruption of normal protein synthesis ...
Integration of the HIV-1 viral DNA generated by reverse transcription of the RNA genome into the host cell chromosomes is a key step of viral replication, catalyzed by the viral integrase. In October 2007, the first integrase inhibitor, raltegravir, was