Small molecule drugs can affect clearance of monoclonal antibodies, but this hasn’t been assessed for oral HIV-1 pre-exposure prophylaxis. Here, the authors find that faster serum clearance of an experimental IgG1 monoclonal antibody, VRC01, is associated with use of tenofovir-emtricitabine, possi...
Antivirals; anti-HIV drugs with other mechanism of action to prevent cross-resistancedoi:US20070249687 A1R 3 is hydrogen, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted amino, optionally substituted ...
What is the mechanism of action of NRTIs? NRTI stands for nucleoside/nucleotide reverse transcriptase inhibitor. They block an enzyme that HIV needs to make more copies of itself. Can you get HIV from someone who is undetectable? No. If HIV is undetectable in a person, they cannot spread HI...
Louis Picker focused the second part of the Harvard CIAR talk on understanding the mechanism of action of CMV/SIV vaccines. The overall efficacy of RhCMV vectors in clearing infection is 55% (against SIVmac239) when given prophylactically [3]. The unique protection pattern involved an ‘effect...
41,46,48,50,52 Myocardial fibrosis is likely to be a key pathogenic mechanism in the cardiovascular morbidity and mortality observed in people living with HIV.72,73 The underlying etiology of HIV-associated cardiac pathology and whether its association observed with HIV remains true in regions of...
“I have had clients [ask me to do drugs], but I charge more. For 40 soles I’m not going to smoke…I prefer to earn a little more if I’m going to damage my little brain cells when I smoke. That’s why I don’t smoke” (21-year-old). ...
A hallucinogen-like mechanism of action is also consistent with reports of hallucinations, vivid dreaming, and psy- chosis as part of a range of adverse psychiatric events that have been reported as dose-dependent side effects for efavirenz when used orally as an antiretroviral medication to treat...
Cell cultures, tissues, and whole organisms are good systems for examining the action of CPPs under in vivo conditions, but the use of a simple and well-defined model system provides a better chance to show the molecular mechanism of passive protein transduction. We used high-speed single-mole...
Opioid use is escalating in North America and comes with a multitude of health consequences, including HIV and hepatitis C virus (HCV) outbreaks among persons who inject drugs (PWID). HIV pre-exposure prophylaxis (PrEP) and HCV treatment regimens have tr
Researchers in Madrid, Spain are planning toinvestigate the effectson the tissue HIV reservoir of higher than usual doses of the antiretroviral drugs dolutegravir, maraviroc, and lamivudine. Whilemost studieshave concluded that current antiretroviral therapy (ART) regimens completely suppress HIV replicatio...