The Mechanism of Action for Drugs that Undermine HIV-1 Viral Capsid Formation and Activity: Insights from Large-Scale Coarse-Grained Simulationsdoi:10.1016/j.bpj.2018.11.378Alexander J. PakJohn M.A. GrimeGregory A. VothBiophysical Journal
Small molecule drugs can affect clearance of monoclonal antibodies, but this hasn’t been assessed for oral HIV-1 pre-exposure prophylaxis. Here, the authors find that faster serum clearance of an experimental IgG1 monoclonal antibody, VRC01, is associated with use of tenofovir-emtricitabine, possi...
This suggests that Vpu has at least one additional mechanism used for counteracting BST-2/Tetherin. The S52/56 mutations also no longer affected Vpu activity against BST-2/Tetherin in the knockout cell line. This is consistent with previous findings that Vpu and BST-2/Tetherin interact using ...
This class of drugs works by blocking the protein shell of the HIV-1 virus, known as the capsid.Lenacapavir(Sunlenca) is initially given as oral tablets and subcutaneous injections, followed by maintenance injections every six months. You'll take it in combination with other antiretroviral(s)....
A hallucinogen-like mechanism of action is also consistent with reports of hallucinations, vivid dreaming, and psy- chosis as part of a range of adverse psychiatric events that have been reported as dose-dependent side effects for efavirenz when used orally as an antiretroviral medication to treat...
Mechanism of HIV antiretroviral drugs progress toward drug resistance. Fundam. Clin. Pharm. 2012, 26, 146-161.Ammaranond, P., Sanguansittianan, S., Mechanism of HIV antiretroviral drugs progress toward drug resistance. Fundam. Clin. Pharmacol., 2012; 26(1): 146-161. DOI: 10.1111/j.1472...
Mechanism of HIV Infection Once in the body, HIV attaches to several types of white blood cells. The most important are certain helper T lymphocytes (T cells). Helper T lymphocytes activate and coordinate other cells of the immune system. On their surface, these lymphocytes h...
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. A better understanding of the structure and function(s) of RT and of the mechanism(s) of inhibition can be used to generate better drugs; in ... SG Sarafianos,B Marchand,K Das,......
41,46,48,50,52 Myocardial fibrosis is likely to be a key pathogenic mechanism in the cardiovascular morbidity and mortality observed in people living with HIV.72,73 The underlying etiology of HIV-associated cardiac pathology and whether its association observed with HIV remains true in regions of...
30 Thus, although capsid association with CPSF6 and localization of RTC/PICs to NS regions proximal to transcriptionally active sites is conserved between MDMs17,42,52 and resting CD4 T cells, relevant differences exist in the dynamics of post-entry replication strategies and the mechanism of Vpx...