HIV vaccines: the effect of the mode of action on the coexistence of HIV subtypes. Math Popul Stud. 2000;8:205-229.T.C.Porco, S.M. Blower, HIV vaccines: The Effect of the mode of action on the coexistence of HIV subtypes, Math. Pop. Studies 8 (2) (2000), p. 205-229. ...
Dissecting the mode of action of various HIV-inhibitor classes in a stable cellular system 来自 掌桥科研 喜欢 0 阅读量: 47 作者:T Klimkait,F Stauffer,E Lupo,C Sonderegger-Rubli 摘要: We describe a stable and sensitive HIV evaluation system, which discriminates HIV-specific membrane fusion and...
摘要: The molecular mode of action of 3-amino-3-deoxythymidine 5- triphosphate in the polymerization reaction catalyzed by human immunodeficiency vim reverse transcriptase was elucidated. This compound was shown to be a termination substrate on both DNA and RNA templates....
The molecular basis of latency—defined as HIV DNA integrated in the host genome but remaining transcriptionally inactive—is complex and may involve multiple mechanisms contributing to transcriptional repression simultaneously. This topic has been extensively reviewed elsewhere30and include the following mecha...
we report the antiretroviral activity ofWithania somniferaroot extracts as well as their mode of action against HIV-1 infection. We also identified the active metabolites of the plant that might be proven as the essential negative regulators of HIV-1 replication throughin silicomolecular docking studi...
To estimate the prevalence of sex trafficking as a mode of entry into sex work, and to examine associations between sex trafficking and recent violence experiences and HIV vulnerability among female sex workers (FSWs). In a cross-sectional study in 2006 in coastal Andhra Pradesh, India, 812 FSW...
We demonstrate that Ci extracts show broad inhibitory activity against different HIV isolates, including a clinical virus isolate with multiple resistances against conventional drugs. Mode-of-action studies demonstrate that Ci extracts target viral envelope proteins, preventing the primary attachment of the...
Their antiviral activity in cell culture was mitigated by the development of resistance mutations in the IN protein, thereby confirming their mode of action [9]. These compounds, exemplified by L-731988 [10], were found to inhibit strand transfer with much higher potency (half-inhibitory ...
Availability of anti-retroviral treatment has changed HIV in to a manageable chronic disease, making effective self-management essential. However, only a few studies in low- and middle-income countries (LMICs) reported experiences of people living with H
Here, we describe that Dolabelladienetriol blocked the synthesis and integration of HIV-1 provirus and completely abrogated viral replication in primary cells. Also, studies of kinetic mode of action revealed that the Dolabelladienetriol is a nonnucleoside RT inhibitor (NNRTI), acting as a non...