Mechanism of Action of Estrogen and its Relationship to Toxicological AssessmentEstrogens are steroid hormones, produced primarily by the ovary, which are necessary for normal reproductive function in the female of the species. Yet, estrogens may also be toxic substances under certain circumstances. The...
The results indicate that estradiol acts, following FPH stimulation, at one or more steps subsequent to elevation of cAMP levels to regulate intrafollicular progesterone accumulation and oocyte maturation. Estrogen appears to directly influence the enzymatic (3β-HSD) conversion of pregnenolone to ...
Primary cultures of human endometrial cells were used to examine the direct effects of estrogens on progesterone receptor levels in vitro. Cells, grown in ... RL Eckert 被引量: 1发表: 1981年 The effect of estrogen and androgen on androgen receptors and mRNA levels in uterine leiomyoma, myometr...
The term selective estrogen receptor modulator (SERM) describes a group of pharmaceuticals that manifest estrogen receptor (ER) agonist activity in some tissues but opposes estrogen action in others. Although the name describing this class of drugs is new, the concept is not, as compounds exhibiting...
Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. C. Molecular mechanism of action at estrogen receptor ␣ of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Endocrinology, 142: ......
1: Estrogen Antagonists AROMATASE INHIBITORS, THEIR PHARMACOLOGY AND APPLICATION ANTIESTROGEN PHARMACOLOGY AND MECHANISM OF ACTION CELLULAR AND MOLECULAR MECHANISM OF ACTION OF ANTIESTROGENS GUIDE-LINES IN THE DESIGN OF NEW ANTIESTROGENS AND CYTOTOXIC-LINKED ESTROGENS FOR THE TREATMENT OF BREAST CANCER 2:...
Mechanism of action of estrogen on intramembranous bone formation: regulation of osteoblast differentiation and activity. Endocrinology, 1992;131:883-9... R,T,Turner,... - 《Endocrinology》 被引量: 145发表: 1992年 FGF2 stimulation of osteoblast differentiation and bone formation is mediated by mod...
Molecular Mechanism of Action of Selective Estrogen Receptor Modulator in Target Tissues The risk of cardiovascular disease steeply increases after menopause. Many epidemiological and basic studies have shown that estrogen has significant funct... M Ohmichi,K Tasaka,H Kurachi,... - 《Endocrine Journal...
Estrogen receptorsBolandiol is a synthetic anabolic steroid that increases lean body mass and bone mineral density without significant stimulation of sex accessory glands in castrate adult male rats. Since bolandiol suppresses gonadotropins and endogenous testosterone (T) production, we investigated its ...
Treatment of immature female rats with estrogen resulted in the induction of a peroxidase in the uterus which is able to convert estradiol-4-14C to water-soluble products in vitro. It is suggested that this reaction may be part of an adaptive response to limit the duration of action of ...