It is shown that sensitivity analysis brings deeper insight into human body injury criteria. The sensitivity coefficients could be incorporated into existing injury criteria such as Severity Index (SI) and Head Injury Criteria (HIC), or they could be used independently.Iztok Ciglaric...
The catabolic response to sepsis, severe injury, and burn is characterized by whole-body protein loss, mainly reflecting increased breakdown of muscle prot... Curtis,J,Wray,... - 《Nutrition》 被引量: 229发表: 2002年 Cellular and molecular aspects of contractile dysfunction in heart failure A...
The present study was undertaken to study the combined effects of compression injury, tumor necrosis factor α (TNFα), and interleukin-6 (IL-6) and its soluble receptor (sIL-6R) on immature bovine and adult human knee and ankle cartilage, using an in vitro model, and to test the ...
By 15 days after MV, most lung injury had resolved without treatment. Conclusions: Extremely immature lungs, particularly bronchioles, are severely injured by 2 h of MV. In the absence of continued ventilation these injured lungs are capable of repair. At 24 h after MV, genes associated with ...
Characterization of neural mechanotransduction response in human traumatic brain injury organoid model Article Open access 19 August 2023 Introduction Brain tissue is highly sensitive to mechanical impacts. Mechanically induced brain injuries are usually characterized by diffusely distributed axonal and vascular...
Influence of knee joint angle on muscle properties of paralyzed and nonparalyzed human knee extensors Muscles of individuals with a spinal cord injury (SCI) exhibit an unexpected leftward shift in the force (torque)-frequency relationship. We investigated w... KH Gerrits,CN Maganaris,ND Reeves...
118 In chondrocytes, PIEZO1 and PIEZO2 can act redundantly to mediate injury-induced osteoarthritis.119 In vivo studies have demonstrated the indispensability of PIEZO1 in the osteoblastic lineage, albeit with various phenotypes. Several single-nucleotide polymorphisms (SNPs) of PIEZO1 were associated...
mechanical injury is present, leading to an uneven load bearing in localized areas of the joint [21]. The inflammatory response would then be considered an attempt by the joint to fix the atypical stress distribution and repair the osteoarthritic injury [21,43], leading to an increase in ...
Under pathophysiological states such as inflammation or nerve injury, Piezo2 genetic knockout or antisense RNA knockdown from sensory neurons impairs nocifensive responses to somatic and visceral mechanical sti- mulation, suggesting the role of Piezo2 in mechanical allodynia26,28,29. The Piezo channels...
Notably, there is a growing interest in mechanically sensitive proteins, both in in vivo and in vitro studies. Among these proteins, TGF-β stands out as a well-established key cytokine that regulates the response of fibroblasts to injury and the pathological development of fibrosis [19]. Brief...