Ultra-short regimenBackground: Multidrug-resistant tuberculosis (MDR-TB) are unsatisfied to treat, pressing more effective and innovative treatment regimens. New efficient regimens for MDR-TB have obtained high treatment success rates. However, those regimens without drug susceptibility testing (DST) are...
世界卫生组织(WHO)2021年发布的全球结核病报告显示,耐多药结核病(MDR-TB)的全球治愈率只有59%,是严重威胁全球公共卫生的重大传染性疾病。临床上MDR-TB患者常因为不恰当的治疗、依从性差、抗结核药物治疗方案不合…
Patients undergoing MDR-TB treatment must go through a regimen so physically and psychologically burdensome that many do not complete it. Historically, treatment for MDR-TB has required a minimum of five drugs for at least 18 months, including a daily injection for at least eight months (“inte...
Alberts Cellular Therapy (Gauteng, South Africa), and once the mechanisms of protection and correlates of beneficial clinical responses in patients with MDR-TB treated with personalised HDTs are better defined, the HDT treatment regimen could potentially be replaced with more generalised biologicals to...
Recent controversies about MDR and XDR-TB: Global implementation of the WHO shorter MDR-TB regimen and bedaquiline for all with MDR-TB?bedaquilineextensively drug-resistant tuberculosismultidrug-resistant tuberculosistreatmentTuberculosis (TB) is now the biggest infectious disease killer worldwide. Although...
The higher rate of treatment success in armed force patients most probably indicates that there is a good efficacy of the standard treatment regimen in armed force society. The adequate follow-up, early identification and management of adverse drug reactions had been mentioned the key to favorable ...
The National Pharmaceutical Pricing Authority (NPPA) has asked all state drug controllers (SDCs) to ensure smooth production and supply of clofazimine across the country used in the treatment of multi drug resistant (MDR) TB. Drug clofazimine is a part of regimen for the treatment of MDR TB un...
For instance, antibiotic resistance is a growing problem in multiple drug-resistant tuberculosis (MDR-TB) infections. …show more content… A person with fully susceptible TB may develop secondary (acquired) resistance during therapy because of inadequate treatment, not taking the prescribed regimen ...
“This has led to more focused case finding of MDR-TB in high-burden settings with improved diagnostic tools, along with better treatment interventions to save lives and decrease transmission. We are still scratching the surface to achieve global control of MDR-TB and XDR-TB, but we know ...
The finding of a low or intermediate resistance level in 16% and 35% of the isolates, respectively, may help in designing an efficient personalized regimen for the treatment of MDR-TB patients. Conclusions The automated DST procedure permits accurate and rapid quantitative resistance profiling of ...