Multiple lines of evidence suggest that SINEs, constituting more than 10% of the human and mouse genome, could serve this function. As mentioned in Section 1, SINEs can be transcribed either by pol II in the form of introns or UTRs, or by pol III as distinct independent transcripts. It ...
Serum from DM patients and control subjects was used to treat mouse lung microvascular endothelial cells (MVECs) to investigate vascular changes. Western blotting, quantitative real-time polymerase chain reaction (qRT-PCR), immunofluorescence staining, immunoprecipitation, protein mass spectrometry, flow ...
To explore the adaptive immune responses in MDA5+DM patients at the single-cell level, we performed scRNA-seq on peripheral B and T cells from seven active MDA5+DM patients (MDA5+DM-Act), three paired MDA5+DM patients in remission (MDA5+DM-Rem), and five IIM disease controls (Ctrl ...