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Additionally, the use of a NOD/SCID mouse xenograft model demonstrated that MCE completely suppressed tumor growth via the down-regulation of proliferating cell nuclear antigen (PCNA) expression without significant change in kidney and liver functions. These results suggest that M. charantia may ...
[6]Suo G,Sadarangani A,Lamarca B,et al.Murine xenograft model for human uterine fibroids:an in vivo imaging approach [J].Reproductive Sci,2009,16(9):827-842. [7]Minn AJ,Gupta GP,Siegel PM,et al.Genes that mediate breast cancer metastasis to lung [J].Nature,2005,436(7050):518-524...
关键词:活体生物发光成像;MDA-MB-231细胞;三阴性乳腺癌;裸鼠;移植瘤模型中图分类号:R737.9 文献标志码:A 文章编号:1673-4254(2011)11-1812-07 EstablishmentofabioluminescentMDA-MB-231celllineforinvivoimagingofhuman triple-negativebreastcancerxenograft 阳4NGKe 1,XIESi-mei 1,HEJia叫un 1 ,RENYu 1,...
A: Sp1 activity in MDA-MB-231 cells; B: Sp1 activity in xenografted tumors after luteolin treatment. *P < 0.05 vs control group. 2.7 MDA-MB-231细胞过表达Sp1后削弱木犀草素上调OPCML表达 将MDA-MB-231细胞转染PL-Sp1载体使其胞内过表达Sp1(图7A),随后用20 μmol /L木犀草素处理72 h后,...
二甲双胍通过下调c-Myc增强人乳腺癌MDA-MB-231细胞对他莫昔芬的敏感性
As proof-of-concept, we show that in vivo knockdown of ASncmtRNAs results in drastic inhibition of tumor growth in a xenograft model of MDA-MB-231 subcutaneous tumors, further supporting this approach for the development of new therapeutic strategies against breast cancer....
(Tokunaga et al, 1998;Yuan et al, 2001) have suggested that VEGF189 has an important role locally in aggressive tumours, especially by delaying tumour growth potential, invasion and migration of xenografted cells, and tumour angiogenesis (Perrot-Applanat and Di Benedetto, 2012). Here our ...
为进一步检测CSN4对乳腺癌细胞增殖能力的影响,本研究检测了干扰CSN4后对乳腺癌细胞克隆形成能力的影响。结果发现,CSN4基因干扰实验组 的克隆细胞数相比对照组 细胞数目少(图3A);重复3次实验后的统计结果表明,差异具有极其显著的统计学意义(图3B)。这说明CSN4基因表达被干扰后能够抑制了乳腺癌细胞MDA-MB-231的细胞...
In this study, we investigated the anti-angiogenic, anti-tumor and anti-metastatic activities of Avastin (Av)22, an anti-VEGF antibody; and Oleamide (OL)23,24,25, a gap junction inhibitor, using MDA-MB-231 human breast cancer cells in vitro and a xenograft murine model in vivo. We show...