We found that the expression of PD-L1 was significantly increased under conditions of extracellular acidosis in MDA-MB-231 cells. We also confirmed that the increased expression of PD-L1 mediated by extracellular acidosis was decreased when the pH was raised to the normal range. Gene set ...
Bos PD, Nguyen DX, Massague´ J (2010) Modeling metastasis in the mouse. Curr Opin Pharmacol 10: 571–577. Dandachi N, Hauser-Kronberger C, More´ E, Wiesener B, Hacker GW, Dietze O, Wirl G (2001) Co-expression of tenascin-C and vimentin in human breast cancer cells indicates ...
We found KHSRP showed higher expression level and was associated with worse prognosis in breast cancer patients. In siKHSRP samples, the proliferation, invasion, and migration abilities were significantly repressed compared with negative control (NC) samples, while the apoptosis level was increased. By...
Significant expression of genes related to mitochondrial processes were highlighted during the RNA-Seq analysis performed in the genetic material within the EVs. Hence, we took a deeper look into those mitochondria-related genes and found that most of them were effectively detected in EVs and downreg...
production, Treg cell's function, CD107a expression, apoptosis, and proliferation was assessed by ELISA and flow cytometry, respectively. Results: The results of this study showed that shPD-1 inhibits PD-1/PD-L1 interaction and enhances T lymphocyte responses through a significant increase in IFN...
PD-L1High-mobility group box1 (HMGB1) is increased in breast cancer cells as the result of exposure to the secreted substances from cancer-associated fibroblasts and plays a crucial role in cancer progression and drug resistance. Its effect, however, on the expression of programmed death ligand ...
Özgül Özdemir, R.B.; Özdemir, A.T.; Kırmaz, C.; Tuğlu, M.İ.; Şenol, Ö.; Özverel, C.S.; Berdeli, A. The Effects of Mesenchymal Stem Cells on theIDO, HLA-G and PD-L1 Expression of Breast Tumor Cells MDA-MB-231 and MCF-7.Arch. Clin. Exp. Med....
In the current study, we adopted siRNA technology to knock down the expression of KIAA0100 in MDA-MB-231 cells, a highly aggressive triple negative breast cancer cell line [20,21], as a model to study its potential molecular and cellular roles associated with aggressive behavior of breast ...