We found that the expression of PD-L1 was significantly increased under conditions of extracellular acidosis in MDA-MB-231 cells. We also confirmed that the increased expression of PD-L1 mediated by extracellular acidosis was decreased when the pH was raised to the normal range. Gene set ...
Whole-genome expression profiling of MDA-MB 231 overexpressing VEGF189 (V189), MDA-MB 231 overexpressing VEGF165 (V165) or control cells (cV) was carried out with AffymetrixGeneChip Human Gene 1.0 ST arrays. Similarly, MDA-MB-231-derived lung metastases obtained after the intracardiac injection ...
KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells Xuelaiti Paizula, Aliya Wulaying, Dong Chen & Jianghua Ou Scientific Reports volume 14, Article number: 14694 (2024) Cite this article 895 Accesses 2 Cit...
3.2. Effect of hBM-MSC-cm on the Expression of Immunomodulatory Genes in MDA-MB-231 and BT-474 Cells It is known that cancer-derived cell lines produce a series of cytokines that can, in turn, modify the local immune response. Thus, to answer the question of whether hBM-MSC-cm can mo...
Figure 4A shows MDA-MB-231 cells that were able to penetrate the BME barrier in mock control and negative siRNA transfected cells were at a similar level without significant difference (p > 0.05). In contrast, silencing the expression of KIAA0100 significantly reduced the number of cells that ...
去除其中部分与检索策略重复的主题词,分析该领域关键词的共现频次及其中心值可知,热点关键词为细胞程序性死亡配体1表达(PD-L1 expression)、肿瘤突变负荷(tumor mutational burden)、表皮生长因子受体突变(EGFR mutation)、肿瘤微环境(tumor microenv...
Presence of mitochondria within MDA-MB-231-derived EVs Significant expression of genes related to mitochondrial processes were highlighted during the RNA-Seq analysis performed in the genetic material within the EVs. Hence, we took a deeper look into those mitochondria-related genes and found that mo...
Moreover, both compounds demonstrated immunomodulatory properties, attenuating PD-L1 expression in MDA-MB-231 cells. Conclusion: TPT-ITC was more effective in down-regulating CD44 expression and reducing migration than TBT-ITC, while TBT-ITC was more potent in lowering PD-L1 expression in comparison...
Results: The results of this study showed that shPD-1 inhibits PD-1/PD-L1 interaction and enhances T lymphocyte responses through a significant increase in IFN? production and CD107a expression. In addition, in the presence of shPD-1, the percentage of Treg cells decreased, while MDA-MB-...
HMGB1 mediates invasion and PD-L1 expression through RAGE-PI3K/AKT signaling pathway in MDA-MB-231 breast cancer cellsBreast cancerHMGB1RAGEPI3K-AKTMigrationInvasionPD-L1High-mobility group box1 (HMGB1) is increased in breast cancer cells as the result of exposure to the secreted substances from ...