BET-directed PROTACs in triple negative breast cancer cell lines MDA-MB-231 and MDA-MB-436Triple negative breast cancerBETPROTACARV-771MZ1HER2Purpose This study aims to find whether the proliferation and migration of triple negative breast cancer (TNBC) cell lines can be reduced by treatment ...
因此,在裸鼠体内建立第 11 期王坷,等.用于活体成像的人三阴性乳腺癌 MDA-MB-231 细胞系的构建 . 1813 • 人 TNBC 细胞的脑转移瘤模型可以深入研究 TNBC 细胞高脑转移能力的内在机制,为进一步找到遏制其高脑转移能力的治疗靶点提供依据。活体内生物发光成像技术是目前最先进的活体内肿瘤细胞追踪技术之→[6-7]...
To characterize the EVs release, serum-starved TNBC-derived MDA-MB-231 cells were cultured in the presence or absence of 30 µM EGCG for 48 h. A concentration documented to not alter MDA-MB-231 cell viability [45,46,47]. Conditioned media was next collected, and EVs were isolated as ...
Methods We introduced ARs into the MDA-MB-231 strain of TNBC cells by using the pEGFP-C1-AR plasmid vector, establishing a stable AR-forced expression... Y Asano,S Kashiwagi,R Kouhashi,... - 《Annals of Oncology》 被引量: 0发表: 0年站...
本课题组前期研究发现,丝胶蛋白可抑制TNBC细胞的增殖,但具体机制尚待深入探讨.本研究旨在观察丝胶蛋白作用下TNBC MDA-MB-468细胞自噬相关指标的变化,研究丝胶蛋白是否通过PI3K/Akt/m TOR信号转导通路诱导自噬,并试图探明丝胶诱导MDA-MB-468细胞自噬的作用靶点.目的:观察丝胶蛋白对TNBC MDA-MB-468细胞PI3K/Akt/m TOR...
MB-468细胞增殖,侵袭和迁移能力降低,凋亡率升高(均P<0.05或P<0.01).双荧光素酶报告基因和实验证实BIN1是miR-28-3p的靶基因,miR-28-3p抑制剂可上调MDA-MB-468细胞中BIN1蛋白的表达(P<0.05).结论:miR-28-3p在TNBC组织及细胞中呈高表达状态,miR-28-3p抑制剂上调BIN1表达进而抑制MDA-MB-468细胞的增殖,迁移...
Interestingly, the combination of the curcumin derivative TL3 with doxorubicin and cisplatin displayed a synergistic effect in TNBC cells.doi:10.3390/ijms25137446Maria RosGerard Riesco-LlachEmma Polonio-AlcaláPere Miquel Morla-BarceloSantiago Ruiz-Martínez...
CuE suppresses DNA synthesis in MDA-MB-468 and SW527 TNBC cell lines.Yanjie KongJianchao ChenZhongmei ZhouHoujun XiaMingHua QiuCeshi Chen
CuE induces apoptosis in MDA-MB-468 and SW527 TNBC cell lines.Yanjie KongJianchao ChenZhongmei ZhouHoujun XiaMingHua QiuCeshi Chen
The therapeutic effect and mechanism of a novel long-acting second-generation proteasome inhibitor (SGPI) in MDA-MB-231 TNBC cells - Journal of the American College of Surgeonsdoi:10.1016/j.jamcollsurg.2014.07.861Vyas, DineshTong, Yixin