Expression levels of MCM3AP Antisense RNA 1 (MCM3AP-AS1), microRNA-126 (miR-126), and vascular endothelial growth factor (VEGF) in tissues and transfetced cells were measured by RT-qPCR. Cell transfections were performed to explore the interaction among MCM3AP-AS1, miR-126 and VEGF. ...
Yuwei Zou1, Jin Xu1 and Li Zhang1* Abstract Background: Although the fact that long non-coding RNA MCM3AP antisense RNA 1 (MCM3AP-AS1) is oncogenic in several cancers is well documented, very few researchers investigate its expression and function in prostate cancer. ...
Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed i
Although the fact that long non-coding RNA MCM3AP antisense RNA 1 (MCM3AP-AS1) is oncogenic in several cancers is well documented, very few researchers investigate its expression and function in prostate cancer. Methods Paired prostate cancer samples were selected, and expressions of MCM3AP-AS1...
目的:探讨长链非编码RNA(long noncoding RNA,LncRNA)MCM3AP-AS1在乳腺癌患者中的表达及其临床病理意义。方法:收集老年女性(年龄≥60岁)晚期乳腺癌患者肿瘤组织穿刺标本64例,应用qRT-PCR技术检测肿瘤组织中的LncRNA MCM3AP-AS1表达情况,免疫组化检测乳腺癌组织样本中的雌激素受体(estrogen re...
骨肉瘤组织中MCM3AP-AS1的表达水平升高(P<0.05),miR-335的表达水平降低(P<0.05);转染si-MCM3AP-AS1可明显降低光密度值及Bcl-2蛋白水平,减少克隆形成数,提高凋亡率及Bax蛋白水平(P<0.05);双荧光素酶报告实验证实MCM3AP-AS1可靶向结合miR-335;转染miR-335 inhibitor可明显逆转干扰MCM3AP-AS1对U2OS细胞增殖及...
The results also demonstrated that MCM3AP-AS1 promoted CRC cell progression by regulating the miR-599/ARPP19 axis. Taken together, the results of the present study suggest that MCM3AP-AS1 may be a novel therapeutic target for patients with CRC. Copyright: Yu et al....
LncRNA MCM3AP-AS1Dkk1骨转移预后目的:探讨长链非编码RNA(long noncoding RNA,LncRNA)MCM3AP?AS1在乳腺癌患者中的表达及其临床病理意义.方法:收集老年女性(年龄≥60岁)晚期乳腺癌患者肿瘤组织穿刺标本64例,应用qRT?PCR技术检测肿瘤组织中的LncRNA MCM3AP?AS1表达情况,免疫组化检测乳腺癌组织样本中的雌激素受体(...
MCM3AP-AS1癌症结直肠癌预后目的:随着高通量测序技术的进步,大量研究发现长链非编码RNA(long non-coding RNA,lnc RNA)可作为一种新的诊断和预后生物标志物,并可能为临床提供新的治疗靶点.近期研究表明,MCM3AP反义RNA 1(MCM3AP antisense RNA 1,MCM3AP-AS1)在多种癌症中异常表达,参与肿瘤的发生,发展和转移....
It was found that MCM3AP-AS1 was declined in OA cartilage tissues, positively interrelated with SIRT1 expression while negatively correlated with miR-138-5p. MCM3AP-AS1 up-regulation enhanced the viability and migration of CHON-001 and ATDC5 cells while restraining the apoptosis and inflammatory ...