研究还发现,丙泊酚可以通过程序性细胞死亡配体1(programmed death-ligand 1,PD-L1)/Nanog通路减少乳腺癌干细胞的形成[11]。本研究检测丙泊酚对人乳腺癌MCF-7细胞增殖活力以及迁移、侵袭和血管形成能力的影响,并探讨其可能的分子作用机制是否与下调STAT3磷酸化有关。 1、材料与方法 1.1主要材料 人乳腺癌细胞株MCF-7用...
研究还发现,丙泊酚可以通过程序性细胞死亡配体1(programmed death-ligand 1,PD-L1)/Nanog通路减少乳腺癌干细胞的形成[11]。本研究检测丙泊酚对人乳腺癌MCF-7细胞增殖活力以及迁移、侵袭和血管形成能力的影响,并探讨其可能的分子作用机制是否...
The antagonistic effect of PD-L1 binding on EGFR was activated inducing apoptosis in gastric cancer cells. The EGFR pathway controls the manifestation of PD-L1 in EGFR-mutant NSCLC via IL6/JAK/STAT3 signaling. PD-L1 expression in tumors may be connected to EGFR-mediated lipid metabolism ...
含量测定山柰素110861-200808常温,避光20mgPDCD1LG2重组小鼠 B7-DC / PD-L2 / CD273 蛋白 (His 标签) ProteinRhesus antibody Rh C19orf47 19号染色体开放阅读框47抗体 规格 0.2ml 含量测定银杏内酯C(暂行)110864-200505常温,避光20mgIL12A & IL12B重组小鼠 IL-12 (IL12A & IL12B Heterodimer) 蛋白 ProteinRhes...
新藤黄酸抑制人乳腺癌细胞株MCF-7增殖的实验研究
PD n — I45bp hTl -RT 图I RT — PCR 检测结果 M :marker 1 :pS ilence r 3 .1 一H 1 neo 2 :pS ilencer 3 .1 一H I neo — shTER T1 3 :pS ilencer 3 .1 一H 1 neo — shTERT2 I 2 3 4 图2 图2 western blot 蛋 白质检测 ...
RNA was collected from CD3+ T cells after co-culture with MCF7 cells, and the expression of immune-related inflammatory molecules (CTLA-4, IFN-γ, CCL5, IL-12A, IL-10, PD-1, PD-L1, IL-2) was assessed by qPCR (Fig. 4A, B). Among these immunoinflammatory molecules, IFN-γ was ...
(Palo Alto, CA), dual-luciferase reporter assay system from Promega (Madison, CA), ECL™ western blotting detection reagents from Amersham Biosciences (Little Chalfont, Buckinghamshire, UK), BSA protein assay kit from Pierce (Rockford, IL), and U0126, LY294002, AKT inhibitor IV and PD98059...
PD OX could im pro v e th e ef j[icac y an d re du ce the ov era ll tox ic ity, bu t in th is stu dy, w e assessed the antitumor ef- fects an d toxicifi es Of D O X and PD O X in p atient-deri ved M CF 一7 b reast c anc er cells in vitro. ...
SH003PD-L1Drug resistanceSTAT3Doxorubicin[Display omitted]doi:10.1016/j.phyplu.2021.100111Jin Mo KuDepartment of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Kyungheedae-ro 26, Dongdaemun-gu, Seoul 02447, Republic of KoreaSe Hyang Hong...