McCune-Albright syndrome (MAS) is characterized by the clinical triad of polyostotic fibrous dysplasia, cafe-au-lait pigmented skin lesions, and multiple endocrinopathies. The molecular basis of MAS is a mutation in G(s)alpha that results in constitutive activation of adenylyl cyclase in ...
McCune-Albright syndrome. McCune-Albright syndrome (MAS) is characterized by the clinical triad of polyostotic fibrous dysplasia, cafe-au-lait pigmented skin lesions, and multiple e... WF Schwindinger,MA Levine - 《Trends in Endocrinology & Metabolism Tem》 被引量: 30发表: 1993年 Activating ...
cafe-au-lait spots. FD, mostly polyostotic, causes fractures needing surgical and orthopedic treatment. Since previous studies have suggested the overall prognosis of patients with McCune-Albright syndrome to be non-fatal, recent data have drawn our attention to non-endocrine affections, including ...
MCCUNE-ALBRIGHT综合征的临床研究及基因诊断 上海交通大学 硕士学位论文 McCune-Albright综合征的临床研究及基因诊断 姓名：*** 申请学位级别：硕士 专业：内科学（内分泌代谢病）指导教师：*** 20070430
(cafe-au-laitspots)d. Hepatobiliarydysfunctione. Cardiacdiseasef. Othernon-endocrinemanifestationsIV.SummaryReferencesABSTRACTTheclassicaltriadofMcCune-Albrightsyndrome(MAS)consistsofpolyostoticfibrousdysplasia(FD),skinhyperpigmentation(cafe-au-laitspots),andendocrinedysfunction,fre-quentlyseeninfemalesasprecocious...
We present a patient with hyperthyroidism associated with McCune-Albright syndrome (MAS). MAS is a sporadic genetic disease characterized by polyostotic fibrous dysplasia, cafe au lait cutaneous spots and endocrinopathies (peripheral precocious puberty, thyroidopathies, acromegaly, etc.). It is cause...
The McCune-Albright syndrome is characterized by cafe-au-lait spots, precocious puberty and fibrous dysplasia. It is due to mutations in the gene encoding the Gs protein alpha subunit coupling 7-transmembrane-domain receptors to adenylate cyclase, leading to constitutive adenylate cyclase activation an...
Severe bone deformities involving almost all bones have not been described previously and this prompted us to present the current case. 展开 关键词: Cafe-au-lait macules McCune-Albright syndrome polyostotic fibrous dysplasia DOI: 10.4103/0378-6323.72473 被引量: 1 年份: 2010 ...
Background: Acromegaly, which may be present in patients with McCune-Albright syndrome (MCAS), in association with café-au-lait spots, precocious puberty, and fibrous dysplasia, is often difficult to treat surgically because skull base bone dysplasia prevents the removal of the pituitary adenoma...
关键词:McCune-Albright综合征,肢端肥大症,Gsα,突变 上海交通大学医学院硕士学位论文 6 ClinicalResearchandGeneticDiagnosis onMcCune-AlbrightSyndrome ABSTRACT ObjectiveMcCune-Albrightsyndrome(MAS)isasporadicdisorder characterizedbytheclassictriadofpolyostoticfibrousdysplasia,cafe-au-lait skinpigmentation,andhyperfunct...